Phenotypes associated with this allele

• Allele Symbol: Mycn^tm1.1Mlit
• Allele Name: targeted mutation 1.1, Jian Fei
• Allele ID: MGI:5495991
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Mycn^tm1.1Mlit/Mycn^tm1.1Mlit Tg(CAG-tTS)1Mlit/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J	MGI:5496040

Genotype
MGI:5496040

cx1

• Allelic Composition: Mycn^tm1.1Mlit/Mycn^tm1.1Mlit; Tg(CAG-tTS)1Mlit/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:196015 )

N • doxycycline-treated mice exhibit normal postnatal survival

embryonic lethality during organogenesis, complete penetrance ( J:196015 )

• mice begin to die at E10.5 and are all dead by E13.5

• however, treatment with doxycycline rescues embryonic lethality

nervous system

abnormal cerebellum development ( J:196015 )

• severity of defects depends on doxycycline administration, especially during P2 to P11

decreased brain size ( J:196015 )

• at 12 weeks in mice from dams treated with doxycycline for a day at E0.5

decreased brain weight ( J:196015 )

• at 12 weeks in mice from dams treated with doxycycline for a day at E0.5

decreased cerebellar granule cell number ( J:196015 )

• at 12 weeks in mice from dams treated with doxycycline for a day at E0.5

small cerebellum ( J:196015 )

• at 12 weeks in mice from dams treated with doxycycline for a day at E0.5

limbs/digits/tail

syndactyly ( J:196015 )

• to different degrees in mice from dams treated with doxycycline for a day at E0.5

• failure of separation of soft tissue between adjacent fingers

growth/size/body

growth/size/body region phenotype ( J:196015 )

N • doxycycline-treated mice exhibit normal body weight