Mycn^tm1.1Mlit
Targeted Allele Detail

Summary

• Symbol: Mycn^tm1.1Mlit
• Name: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; targeted mutation 1.1, Jian Fei
• MGI ID: MGI:5495991
• Synonyms: Nmyc^TRE
• Gene: Mycn Location: Chr12:12986094-12991837 bp, - strand Genetic Position: Chr12, 6.14 cM, cytoband A3-B
• Alliance: Mycn^tm1.1Mlit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196015
• Parent Cell Line: PRX-129S6 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The targeting construct inserted tetracycline response element (TRE or tetO) and a loxP site into intron 1 and fused EGFP, FRT-flanked neomycin resistance cassette and an additional loxP site to the ATG translation initiation site in exon 2. Cre-mediated recombination removed EGFP and FRT-flanked neomycin resistance cassette. (J:196015)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mycn Mutation: 24 strains or lines available

References

• Original: J:196015 Sun R, et al., Inducible and reversible regulation of endogenous gene in mouse. Nucleic Acids Res. 2012 Nov;40(21):e166
• All: 2 reference(s)