Phenotypes associated with this allele

• Allele Symbol: Rr27⁺
• Allele Name: wild type
• Allele ID: MGI:5489786
• Summary: 19 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rr27^tm4Msb/Rr27^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3620117
ht2	Rr27^tm1.1Msb/Rr27^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3620113
ht3	Rr27^tm2Wrk/Rr27^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3511783
ht4	Rr27^tm3Msb/Rr27^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3620115
ht5	Rr27^tm6.1Msb/Rr27^+	involves: 129P2/OlaHsd * C57BL/6 * M. m. castaneus	MGI:5140215
ht6	Rr27^tm5.1Msb/Rr27^+	involves: 129P2/OlaHsd * C57BL/6 * M. m. castaneus	MGI:5140213
ht7	Rr27^tm7.1Msb/Rr27^+	involves: 129P2/OlaHsd * C57BL/6 * M. m. castaneus	MGI:5575371
ht8	Rr27^tm2Tilg/Rr27^+	involves: 129S1/Sv	MGI:3719443
ht9	Rr27^tm1Tilg/Rr27^+	involves: 129S1/Sv	MGI:3815532
ht10	Rr27^tm2.1Pes/Rr27^+	involves: 129S1/Sv * 129S1/SvImJ * CAST/Ei * FVB/NJ	MGI:5516488
ht11	Rr27^tm1Rohl/Rr27^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3722289
ht12	Rr27^tm1.1Kpfe/Rr27^+	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:3722125
ht13	Rr27^tm1Rohl/Rr27^+	involves: 129S1/Sv * 129X1/SvJ * FVB/N * SD7	MGI:3722287
ht14	Rr27^tm1.1Mnn/Rr27^+	involves: 129S1/Sv * CAST/Ei * FVB/NJ * Swiss	MGI:6753271
ht15	Rr27^tm1Pes/Rr27^+	involves: 129S1/SvImJ * FVB/N-Chr 7^CAST/Ei/J	MGI:3046755
ht16	Rr27^tm1Wrk/Rr27^+	Not Specified	MGI:3050809
cn17	Rr27^tm2Msb/Rr27^+ Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129P2/OlaHsd * C57BL/6 * DBA	MGI:3620114
cn18	Rr27^tm1Kpfe/Rr27^+ Tg(Tpbpa-cre,-EGFP)5Jcc/0	involves: 129S1/Sv * 129X1/SvJ	MGI:7287525
cx19	Apc^Min/Apc^Min Rr27^tm1Rohl/Rr27^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3722288

Genotype
MGI:3620117

ht1

• Allelic Composition: Rr27^tm4Msb/Rr27⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased embryo weight ( J:105567 )

• at E13.5, embryos are 18% heavier than controls when maternally inherited

• at E9.5, embyros are indistiguishable from controls

embryo

increased embryo weight ( J:105567 )

• at E13.5, embryos are 18% heavier than controls when maternally inherited

• at E9.5, embyros are indistiguishable from controls

increased placenta weight ( J:105567 )

• at E13.5, placentas were 40% heavier than controls when maternally inherited

• at E9.5, placenta size is similar to controls

cellular

abnormal imprinting ( J:106218 )

• when paternally inherited, the paternal H19 locus is derepressed and the paternally inherited Igf2 is repressed

• when maternally inherited, the maternal H19 gene is repressed and the Igf2 gene is activated

• embryonic methylataion of the H19 prometer and 5' end is lost

Genotype
MGI:3620113

ht2

• Allelic Composition: Rr27^tm1.1Msb/Rr27⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

growth/size/body

decreased body weight ( J:52162 )

• 93% of control weight when paternally inherited

increased body size ( J:52162 )

• approximately 17% larger in size when maternally inherited

cellular

abnormal imprinting ( J:52162 , J:106218 , J:105567 )

• when paternally inherited, the paternal H19 locus is derepressed and the paternally inherited Igf2 is repressed (J:52162)

• when maternally inherited, the maternal H19 gene is repressed and the Igf2 gene is activated to approximately 1/3 control level (J:52162)

• paternal inheritance results in hypomethylation of the H19 promoter region (J:52162)

• embryonic methylation of the H19 promoter and 5' end is lost (J:106218)

• loss of paternal allele specific methylation (J:105567)

Genotype
MGI:3511783

ht3

• Allelic Composition: Rr27^tm2Wrk/Rr27⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

normal phenotype

no abnormal phenotype detected ( J:91593 )

• growth and placenta weight are normal regardless of the parent from which the allele is inherited

Genotype
MGI:3620115

ht4

• Allelic Composition: Rr27^tm3Msb/Rr27⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

cellular

abnormal imprinting ( J:106218 )

• paternal H19 allele is expressed and Igf2 expression is reduced, particularly in the liver

• maternal Igf2 allele is expressed and H19 expression is reduced

• embryonic methylataion of the H19 prometer and 5' end is lost

Genotype
MGI:5140215

ht5

• Allelic Composition: Rr27^tm6.1Msb/Rr27⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * M. m. castaneus

cellular

abnormal imprinting ( J:173610 )

• when this allele is inherited paternally, mice exhibit loss of imprinted repression of paternal H19

• when this allele is inherited maternally, the locus exhibits hypomethylation

• however, paternal methylation is normal

growth/size/body

growth/size/body region phenotype ( J:173610 )

N • when this allele is inherited amternally, mice exhibit normal body weight

Genotype
MGI:5140213

ht6

• Allelic Composition: Rr27^tm5.1Msb/Rr27⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * M. m. castaneus

cellular

abnormal imprinting ( J:173610 )

• when this allele is inherited paternally, mice exhibit loss of imprinted repression of paternal H19

• however, paternal methylation is normal

• when this allele is inherited maternally, the locus exhibits hypomethylation

growth/size/body

growth/size/body region phenotype ( J:173610 )

N • when this allele is inherited amternally, mice exhibit normal body weight

Genotype
MGI:5575371

ht7

• Allelic Composition: Rr27^tm7.1Msb/Rr27⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * M. m. castaneus

growth/size/body

increased tongue size ( J:211399 )

• tongue weights are also increased in 1 to 6 day old pups

increased birth weight ( J:211399 )

• weight of pups at 1 to 6 days of age is greater than weight of similar controls regardless of maternal or paternal inheritance

• weight difference does not persist in older pups

craniofacial

increased tongue size ( J:211399 )

• tongue weights are also increased in 1 to 6 day old pups

digestive/alimentary system

increased tongue size ( J:211399 )

• tongue weights are also increased in 1 to 6 day old pups

Genotype
MGI:3719443

ht8

• Allelic Composition: Rr27^tm2Tilg/Rr27⁺
• Genetic Background: involves: 129S1/Sv

cellular

cellular phenotype ( J:86440 )

N • while methylation status is reduced imprinting is normal

Genotype
MGI:3815532

ht9

• Allelic Composition: Rr27^tm1Tilg/Rr27⁺
• Genetic Background: involves: 129S1/Sv

cellular

abnormal imprinting ( J:81888 )

• the imprinting that results in reduced expression of the maternal Igf2 allele is defective in these mice

• the mutation leads to reduced maternal H19 expression and enhanced maternal Igf2 expression

growth/size/body

increased body weight ( J:81888 )

• neonates inheriting a mutant maternal allele are 17% heavier than controls

Genotype
MGI:5516488

ht10

• Allelic Composition: Rr27^tm2.1Pes/Rr27⁺
• Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * CAST/Ei * FVB/NJ

cellular

cellular phenotype ( J:195982 )

N • imprinting control region methylation is normal whether this allele is inherited maternally or paternally

Genotype
MGI:3722289

ht11

• Allelic Composition: Rr27^tm1Rohl/Rr27⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:97083 )

• mice have longer crypts than wild-type mice

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:97083 )

• mice have longer crypts than wild-type mice

Genotype
MGI:3722125

ht12

• Allelic Composition: Rr27^tm1.1Kpfe/Rr27⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

cellular

abnormal DNA methylation ( J:82798 )

• paternally inherited H19 is aberrantly expressed due to a decrease in methylation

• maternal expression of Igf2 is increased

Genotype
MGI:3722287

ht13

• Allelic Composition: Rr27^tm1Rohl/Rr27⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * SD7

growth/size/body

increased susceptibility to weight gain ( J:82427 )

• when the allele is inherited maternally, neonatal weight is increased by 11%

cellular

abnormal imprinting ( J:82427 )

• when the allele is inherited maternally, imprinting of Igf2 is lost

Genotype
MGI:6753271

ht14

• Allelic Composition: Rr27^tm1.1Mnn/Rr27⁺
• Genetic Background: involves: 129S1/Sv * CAST/Ei * FVB/NJ * Swiss

cellular

abnormal imprinting ( J:308869 )

• defective paternal imprinting: failure to activate Igf2 expression and suppress of H19 expression on paternal allele

• normal maternal imprinting: suppression of Igf2 expression and activation of H19 expression on maternal allele

embryo

decreased embryo weight ( J:308869 )

• small (50-61% of normal weight) but normally proportioned E18.5 embryos when inheriting paternal allele

• normal when inheriting maternal allele

growth/size/body

decreased embryo weight ( J:308869 )

• small (50-61% of normal weight) but normally proportioned E18.5 embryos when inheriting paternal allele

• normal when inheriting maternal allele

decreased birth body size ( J:308869 )

• small but normally proportioned body when inheriting paternal allele

• normal when inheriting maternal allele

mortality/aging

mortality/aging ( J:308869 )

N • viable, irrespective of maternal/paternal inheritance of allele

Genotype
MGI:3046755

ht15

• Allelic Composition: Rr27^tm1Pes/Rr27⁺
• Genetic Background: involves: 129S1/SvImJ * FVB/N-Chr 7^CAST/Ei/J

embryo

increased placenta weight ( J:91020 )

• at E17.5 the placenta of mutant fetuses are 136% of the weight of wild-type littermates when the mutant allele is inherited maternally

growth/size/body

increased fetal weight ( J:91020 )

• at E17.5 mutant fetuses are 122% of the weight of wild-type littermates when the mutant allele is inherited maternally

limbs/digits/tail

polydactyly ( J:91020 )

• 11 of 13 mutants who inherit the mutant allele maternally display polydactyly of the forepaws

cellular

paternal imprinting ( J:91020 )

Genotype
MGI:3050809

ht16

• Allelic Composition: Rr27^tm1Wrk/Rr27⁺
• Genetic Background: Not Specified

normal phenotype

no abnormal phenotype detected ( J:91713 )

• no abnormalities are seen

Genotype
MGI:3620114

cn17

• Allelic Composition: Rr27^tm2Msb/Rr27⁺; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

cellular

paternal imprinting ( J:105567 )

• paternal allele specific methylation is maintained

• maternal Igf2 allele expression is detected in the neonate liver

• paternal Igf2 allele expression is reduced

Genotype
MGI:7287525

cn18

• Allelic Composition: Rr27^tm1Kpfe/Rr27⁺; Tg(Tpbpa-cre,-EGFP)5Jcc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

embryo

embryo phenotype ( J:325552 )

N • normal fetal and placental weight

N • born at expected Mendelian ratios

abnormal trophoblast giant cell morphology ( J:325552 )

♀ • 96% volume increase of trophoblast giant cells (TGC) in females

abnormal maternal decidual layer morphology ( J:325552 )

• reduced volume

abnormal placenta junctional zone morphology ( J:325552 , J:325552 , J:325552 )

• 3x increase in cell proliferation (J:325552)

• normal apoptosis (J:325552)

♀ • 43% volume increase in females (J:325552)

♀ • 51% volume increase of glycogen cells (GC), 33% of spongiotrophoblasts (SpT) and 96% of trophoblast giant cells (TGC) in females (J:325552)

♀ • 63% increase in number of glycogen cells (GC) in females (J:325552)

♀ • normal distribution and size of glycogen cells (GC) and and spongiotrophoblasts (SpT) in females (J:325552)

♂ • 20% volume increase in males (J:325552)

♂ • 22% spongiotrophoblast (SpT) volume increase in males (J:325552)

♂ • normal distribution and size of spongiotrophoblasts (SpT) and distribution, number and size of glycogen cells (GC) in males (J:325552)

increased spongiotrophoblast cell number ( J:325552 , J:325552 )

♀ • 44% increase in spongiotrophoblast cell number in females (J:325552)

♂ • 34% increase in spongiotrophoblast cell number in males (J:325552)

decreased placental labyrinth size ( J:325552 )

reproductive system

abnormal maternal decidual layer morphology ( J:325552 )

• reduced volume

growth/size/body

growth/size/body region phenotype ( J:325552 )

N • normal fetal and placental weight

Genotype
MGI:3722288

cx19

• Allelic Composition: Apc^Min/Apc^Min; Rr27^tm1Rohl/Rr27⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

neoplasm

increased intestinal adenoma incidence ( J:97083 )

• mice develop twice as many intestinal and colonic adenomas as in Apc^Min homozygotes

increased colon adenoma incidence ( J:97083 )

• mice develop twice as many colonic adenomas as in Apc^Min homozygotes

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:97083 )

• mice have longer crypts than wild-type mice

increased intestinal adenoma incidence ( J:97083 )

• mice develop twice as many intestinal and colonic adenomas as in Apc^Min homozygotes

increased colon adenoma incidence ( J:97083 )

• mice develop twice as many colonic adenomas as in Apc^Min homozygotes

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:97083 )

• mice have longer crypts than wild-type mice