Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation
(14 available);
any
Lyz2 mutation
(41 available)
Sqstm1tm2.1Jmos mutation
(0 available);
any
Sqstm1 mutation
(32 available)
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growth/size/body
N |
• mice fed standard chow or a high fat diet exhibit normal body weight and composition
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homeostasis/metabolism
cellular
N |
• brown adipose tissue exhibits normal mitochondrial function (measured by cox activity)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sqstm1tm2.1Jmos mutation
(0 available);
any
Sqstm1 mutation
(32 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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growth/size/body
N |
• mice fed standard chow or a high fat diet exhibit normal body weight and composition
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behavior/neurological
N |
• mice fed standard chow or a high fat diet exhibit normal food intake
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Speer6-ps1Tg(Alb-cre)21Mgn mutation
(6 available);
any
Speer6-ps1 mutation
(4 available)
Sqstm1tm2.1Jmos mutation
(0 available);
any
Sqstm1 mutation
(32 available)
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growth/size/body
N |
• mice fed standard chow or a high fat diet exhibit normal body weight and composition
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homeostasis/metabolism
liver/biliary system
N |
• mice do not exhibit liver steatosis
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behavior/neurological
N |
• mice fed standard chow or a high fat diet exhibit normal food intake
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sqstm1tm2.1Jmos mutation
(0 available);
any
Sqstm1 mutation
(32 available)
Tg(Fabp4-cre)1Rev mutation
(2 available)
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Enhanced lipid deposition with increased lipid droplet sizes of brown adipose tissue in Sqstm1tm2.1Jmos/Sqstm1tm2.1Jmos Tg(Fabp4-cre)1Rev/0 mice
homeostasis/metabolism
adipose tissue
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• in mice fed standard chow
• however, fat mass is normal in mice fed a high fat diet
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• impaired nonshivering thermogenesis above brown adipose tissue treated with the selective beta-3 adrenergic receptor agonist CL-316,243
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cellular
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• fewer and shorter cristae displaced to the periphery with varying degrees of disorientation in the mitochondria of brown adipose tissue
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• in the mitochondria of brown adipose tissue
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• decreased oxidative capacity in the mitochondria of brown adipose tissue
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growth/size/body
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• in mice fed a high fat diet
• however, lean mass is normal in mice fed standard chow
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• in mice fed standard chow or a high fat diet
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liver/biliary system
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• in mice fed standard chow or a high fat diet
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behavior/neurological
N |
• mice fed standard chow or a high fat diet exhibit normal food intake
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• reduced locomotor activity (total and mean dark but not mean light)
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