All Phenotypes Dclk1<tm1.1(cre/ERT2)Seno> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dclk1^{tm1.1(cre/ERT2)Seno}
targeted mutation 1.1, Hiroshi Seno
MGI:5475100

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dclk1^{tm1.1(cre/ERT2)Seno}/Dclk1^{tm1.1(cre/ERT2)Seno}	C57BL/6-Dclk1^{tm1.1(cre/ERT2)Seno}	MGI:5475204
cn2	Apc^Min/Apc⁺ Dclk1^{tm1.1(cre/ERT2)Seno}/Dclk1⁺ Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^{tm1(HBEGF)Awai}	involves: 129S4/SvJaeSor * C57BL/6	MGI:5475206
cn3	Ctnnb1^tm1Mmt/Ctnnb1⁺ Dclk1^{tm1.1(cre/ERT2)Seno}/Dclk1⁺	involves: 129X1/SvJ * C57BL/6	MGI:5475208
cx4	Apc^Min/Apc⁺ Dclk1^{tm1.1(cre/ERT2)Seno}/Dclk1^{tm1.1(cre/ERT2)Seno}	involves: C57BL/6	MGI:5475210

Allelic Composition	Dclk1^{tm1.1(cre/ERT2)Seno}/Dclk1^{tm1.1(cre/ERT2)Seno}
Genetic Background	C57BL/6-Dclk1^{tm1.1(cre/ERT2)Seno}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk1^{tm1.1(cre/ERT2)Seno} mutation (0 available); any Dclk1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:193873 )

N	• animals show no differences in intestinal structure compared to wild-type animals; numbers of crypts and height of villi are not different from controls

Allelic Composition	Apc^Min/Apc⁺ Dclk1^{tm1.1(cre/ERT2)Seno}/Dclk1⁺ Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^{tm1(HBEGF)Awai}
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Dclk1^{tm1.1(cre/ERT2)Seno} mutation (0 available); any Dclk1 mutation (53 available)
Gt(ROSA)26Sor^{tm1(HBEGF)Awai} mutation (4 available); any Gt(ROSA)26Sor mutation (944 available)
Gt(ROSA)26Sor^tm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (944 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

abnormal tumor morphology ( J:193873 )

• after tamoxifen treatment and a single injection of diphtheria toxin (DT), polyps contain many Dclk1-positive apoptotic tumor cells and are severely injured or collapsed with Dclk1-negative polyps not displaying DT-induced apoptosis

digestive/alimentary system

digestive/alimentary phenotype ( J:193873 )

N	• after tamoxifen treatment and multiple diphtheria toxin injections to ablate Dclk1-positive cells, these cells are absent from the normal intestine with no significant damage to organ architecture observed in the intestine or stomach

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:193873 )

N	• after tamoxifen treatment and multiple diphtheria toxin injections to ablate Dclk1-positive cells, no significant damage in organ architecture is observed in the pancreas or gallbladder

Allelic Composition	Ctnnb1^tm1Mmt/Ctnnb1⁺ Dclk1^{tm1.1(cre/ERT2)Seno}/Dclk1⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Dclk1^{tm1.1(cre/ERT2)Seno} mutation (0 available); any Dclk1 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:193873 )

N	• 40 days after tamoxifen treatment, mice show no detectable polyp development in the small intestine

Allelic Composition	Apc^Min/Apc⁺ Dclk1^{tm1.1(cre/ERT2)Seno}/Dclk1^{tm1.1(cre/ERT2)Seno}
Genetic Background	involves: C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

intestine polyps ( J:193873 )

• Dclk1 mutant homozygotes develop polyps in similar numbers and with similar size distribution as Dclk1 wild-type, Apc^Min/+ controls

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