All Phenotypes Pld1<tm1.1Mafr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pld1^tm1.1Mafr
targeted mutation 1.1, Michael Frohman
MGI:5468471

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pld1^tm1.1Mafr/Pld1^tm1.1Mafr	B6.Cg-Pld1^tm1.1Mafr	MGI:5468549
hm2	Pld1^tm1.1Mafr/Pld1^tm1.1Mafr	Not Specified	MGI:5468551
cx3	Pld1^tm1.1Mafr/Pld1^tm1.1Mafr Pld2^tm1Yaka/Pld2^tm1Yaka	involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	MGI:5468553

Allelic Composition	Pld1^tm1.1Mafr/Pld1^tm1.1Mafr
Genetic Background	B6.Cg-Pld1^tm1.1Mafr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld1^tm1.1Mafr mutation (1 available); any Pld1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

abnormal tumor vascularization ( J:193451 )

• almost complete absence of small blood vessels in implanted tumors due to impaired tumor angiogenesis

decreased metastatic potential ( J:193451 )

• of implanted melanoma cells

decreased tumor growth/size ( J:193451 )

• of implanted B16F10 mouse melanoma or mouse Lewis lung carcinoma cells with massive macrophage infiltration

cardiovascular system

abnormal tumor vascularization ( J:193451 )

• almost complete absence of small blood vessels in implanted tumors due to impaired tumor angiogenesis

decreased angiogenesis ( J:193451 )

• impaired implanted tumor angiogenesis

• no vascularization of VEGF Matrigel plugs (impaired neoangiogenesis)

• decreased endothelial cell emigration and microvessel formation in aortic rings

• however, lung microvascular endothelial cell proliferation is normal

homeostasis/metabolism

abnormal platelet physiology ( J:193451 )

• activated platelets exhibit reduced binding to implanted tumor cells compared with control mice

hematopoietic system

abnormal platelet physiology ( J:193451 )

• activated platelets exhibit reduced binding to implanted tumor cells compared with control mice

Allelic Composition	Pld1^tm1.1Mafr/Pld1^tm1.1Mafr
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld1^tm1.1Mafr mutation (1 available); any Pld1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:192844 )

• mice are healthy and fertile with normal fMLP-induced neutrophil functions and ethanol inhibition of those induced functions

Allelic Composition	Pld1^tm1.1Mafr/Pld1^tm1.1Mafr Pld2^tm1Yaka/Pld2^tm1Yaka
Genetic Background	involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld1^tm1.1Mafr mutation (1 available); any Pld1 mutation (64 available)
Pld2^tm1Yaka mutation (1 available); any Pld2 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:192844 )

• mice are healthy and fertile with normal fMLP-induced neutrophil functions and ethanol inhibition of those induced functions and fMLP-stimulated phosphatidic acid production

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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