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Pld1tm1.1Mafr
Targeted Allele Detail
Summary
Symbol: Pld1tm1.1Mafr
Name: phospholipase D1; targeted mutation 1.1, Michael Frohman
MGI ID: MGI:5468471
Gene: Pld1  Location: Chr3:27992844-28187511 bp, + strand  Genetic Position: Chr3, 11.15 cM
Alliance: Pld1tm1.1Mafr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193451
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 13. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 13. Cre-mediated recombination removed exon 13 and the neo cassette. RT-PCR confirmed the absence of transcript expression in endothelial cells. (J:193451)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pld1 Mutation:  43 strains or lines available
References
Original:  J:193451 Chen Q, et al., Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis. Sci Signal. 2012;5(249):ra79
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory