Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdcp1tm1.2Moas mutation
(1 available);
any
Cdcp1 mutation
(49 available)
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normal phenotype
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• mice are viable and fertile
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdcp1tm1.2Moas mutation
(1 available);
any
Cdcp1 mutation
(49 available)
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normal phenotype
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• mice did not exhibit gross morphologic or behavioral abnormalities
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mortality/aging
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• euthanized 12 weeks after tamoxifen-treatment
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integument
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• in tamoxifen-treated mice, particularly evident on the abdominal skin
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• tamoxifen-treated mice develop more severe epidermal disease (thick skin, hair loss and scaling) compared with control mice
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• 3.5-fold in tamoxifen-treated mice than in control mice
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• in tamoxifen-treated mice, particularly evident on the abdominal skin
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• in tamoxifen-treated mice
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neoplasm
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• accelerated neoplasm development in tamoxifen-treated mice compared with control mice
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• accelerated neoplasm development in tamoxifen-treated mice compared with control mice
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behavior/neurological
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• in tamoxifen-treated mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdcp1tm1.2Moas mutation
(1 available);
any
Cdcp1 mutation
(49 available)
Tg(MMTV-PyVT)634Mul mutation
(2 available)
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mortality/aging
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• mice are euthanized at 12 weeks due to numerous large tumors
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neoplasm
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• accelerated tumorigenesis compared with Tg(MMTV-PyVT)634Mul mice
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• at 12 weeks mice exhibit a 2.6-fold increase in the number of tumors per mouse with an average of 5.7-fold increase in total tumor burden compared with Tg(MMTV-PyVT)634Mul mice
• with lung metastases
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdcp1tm1.2Moas mutation
(1 available);
any
Cdcp1 mutation
(49 available)
Tg(MMTV-PyVT)634Mul mutation
(2 available)
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neoplasm
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• slight compared with Tg(MMTV-PyVT)634Mul mice
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