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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Taf7tm1.1Dss
targeted mutation 1.1, Dinah S Singer
MGI:5430372
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Taf7tm1.1Dss/Taf7tm1.1Dss involves: C57BL/6 MGI:5430374
cn2
 		Taf7tm1.1Dss/Taf7tm1.2Dss
Tg(Lck-cre)1Cwi/0 		involves: C57BL/6 MGI:5430375
cn3
 		Taf7tm1.1Dss/Taf7tm1.2Dss
Tg(Cd8a*-cre)B8Asin/0 		involves: C57BL/6 MGI:5430376


Genotype
MGI:5430374
hm1
Allelic
Composition		 Taf7tm1.1Dss/Taf7tm1.1Dss
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taf7tm1.1Dss mutation (0 available); any Taf7 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:185745 )
• mice die between E3.5 and E5.5

embryo
abnormal embryo development ( J:185745 )
• mice either do not implant or expand




Genotype
MGI:5430375
cn2
Allelic
Composition		 Taf7tm1.1Dss/Taf7tm1.2Dss
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taf7tm1.1Dss mutation (0 available); any Taf7 mutation (19 available)
Taf7tm1.2Dss mutation (0 available); any Taf7 mutation (19 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
small thymus ( J:185745 )
• very small
abnormal thymus physiology ( J:185745 )
• double negative thymocytes exhibit impaired proliferation
abnormal T cell differentiation ( J:185745 )
• mice exhibit defects in the transition from double negative to double positive thymocytes
increased double-negative T cell number ( J:185745 )
• slightly in the thymus

hematopoietic system
small thymus ( J:185745 )
• very small
abnormal thymus physiology ( J:185745 )
• double negative thymocytes exhibit impaired proliferation
abnormal T cell differentiation ( J:185745 )
• mice exhibit defects in the transition from double negative to double positive thymocytes
increased double-negative T cell number ( J:185745 )
• slightly in the thymus

endocrine/exocrine glands
small thymus ( J:185745 )
• very small
abnormal thymus physiology ( J:185745 )
• double negative thymocytes exhibit impaired proliferation




Genotype
MGI:5430376
cn3
Allelic
Composition		 Taf7tm1.1Dss/Taf7tm1.2Dss
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taf7tm1.1Dss mutation (0 available); any Taf7 mutation (19 available)
Taf7tm1.2Dss mutation (0 available); any Taf7 mutation (19 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:185745 )
• after stimulation with either anti-CD3epsilon or a combination of anti-CD3 epsilon and anti-CD28 antibodies in the presence or absence of IL2
abnormal T cell differentiation ( J:185745 )
• modest effect on T cell development
• however, mice exhibit normal differentiation from double positive to single positive thymocyte and differentiation of single positive thymocytes
decreased T cell number ( J:185745 )
• in the lymph nodes
decreased thymocyte number ( J:185745 )
• at the double positive stage

hematopoietic system
decreased T cell proliferation ( J:185745 )
• after stimulation with either anti-CD3epsilon or a combination of anti-CD3 epsilon and anti-CD28 antibodies in the presence or absence of IL2
abnormal T cell differentiation ( J:185745 )
• modest effect on T cell development
• however, mice exhibit normal differentiation from double positive to single positive thymocyte and differentiation of single positive thymocytes
decreased T cell number ( J:185745 )
• in the lymph nodes
decreased thymocyte number ( J:185745 )
• at the double positive stage

endocrine/exocrine glands
decreased thymocyte number ( J:185745 )
• at the double positive stage

cellular
decreased T cell proliferation ( J:185745 )
• after stimulation with either anti-CD3epsilon or a combination of anti-CD3 epsilon and anti-CD28 antibodies in the presence or absence of IL2




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory