All Phenotypes Id2<tm1Xdz> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/Gt(ROSA)26Sor⁺ Id1^tm3Bene/Id1^tm3Bene Id2^tm1Xdz/Id2^tm1Xdz Id3^tm1Zhu/Id3^tm1Zhu	involves: 129S4/SvJaeSor * C57BL/6	MGI:5428955
cn2	Id1^tm3Bene/Id1^tm3Bene Id2^tm1Xdz/Id2^tm1Xdz Id3^tm1Zhu/Id3^tm1Zhu Tg(Nes-cre)1Kln/0	involves: 129S4/SvJaeSor * C57BL/6 * SJL	MGI:5428946
cn3	Id1^tm3Bene/Id1^tm3Bene Id2^tm1Xdz/Id2⁺ Id3^tm1Zhu/Id3^tm1Zhu Tg(Nes-cre)1Kln/0	involves: 129S4/SvJaeSor * C57BL/6 * SJL	MGI:5428947

Allelic Composition	Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/Gt(ROSA)26Sor⁺ Id1^tm3Bene/Id1^tm3Bene Id2^tm1Xdz/Id2^tm1Xdz Id3^tm1Zhu/Id3^tm1Zhu
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl} mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Id1^tm3Bene mutation (0 available); any Id1 mutation (11 available)
Id2^tm1Xdz mutation (0 available); any Id2 mutation (17 available)
Id3^tm1Zhu mutation (1 available); any Id3 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

premature neuronal precursor differentiation ( J:185426 )

• following tamoxifen-treatment of cultured neural stem cells

nervous system

premature neuronal precursor differentiation ( J:185426 )

• following tamoxifen-treatment of cultured neural stem cells

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:185426 )

• nearly all mice die within the first 24 hours after birth

nervous system

abnormal neuron differentiation ( J:185426 )

• at E18.5, neuronal stem cells exhibit altered shape at the apical border compared with control cells

• cultured neural stem cells fail to form primary and secondary neurospheres unlike control cells

premature neuronal precursor differentiation ( J:185426 )

• of neural stem cells in vitro and in vivo as determined by marker expression

abnormal neuronal precursor proliferation ( J:185426 )

• at E18.5, neural stem cell proliferation is reduced with prolonged cell cycle timing and increased probability of exiting the cell cycle compared with control cells

abnormal brain morphology ( J:185426 )

• hypocellular at E18.5 and P0

abnormal cortical ventricular zone morphology ( J:185426 )

• disrupted pseudo-stratified architecture at E18.5

thin external granule cell layer ( J:185426 )

• at E18.5 and P0

enlarged brain ventricles ( J:185426 )

• at E18.5 and P0

cellular

abnormal cell cycle ( J:185426 )

• at E18.5, neural stem cell proliferation is reduced with prolonged cell cycle timing and increased probability of exiting the cell cycle compared with control cells

abnormal neuron differentiation ( J:185426 )

• at E18.5, neuronal stem cells exhibit altered shape at the apical border compared with control cells

• cultured neural stem cells fail to form primary and secondary neurospheres unlike control cells

premature neuronal precursor differentiation ( J:185426 )

• of neural stem cells in vitro and in vivo as determined by marker expression

abnormal neuronal precursor proliferation ( J:185426 )

• at E18.5, neural stem cell proliferation is reduced with prolonged cell cycle timing and increased probability of exiting the cell cycle compared with control cells

Allelic Composition	Id1^tm3Bene/Id1^tm3Bene Id2^tm1Xdz/Id2⁺ Id3^tm1Zhu/Id3^tm1Zhu Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id1^tm3Bene mutation (0 available); any Id1 mutation (11 available)
Id2^tm1Xdz mutation (0 available); any Id2 mutation (17 available)
Id3^tm1Zhu mutation (1 available); any Id3 mutation (14 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:185426 )

N	• neural stem cells exhibit normal self-renewal and proliferation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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