Analysis Tools
limbs/digits/tail
polydactyly
(
J:31524
)
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• on the hind feet of embryos inheriting the Thp allele from their mother
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• at E12 the base of the tail is constricted; the thickness of the tail itself varies
• at E13 the tail distal to the constriction is thinned
• by E14 the tail is thinned to a filament which often drops off resulting in a blunt-ended tail or tail rudiment
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short tail
(
J:31524
)
|
• shortened by varying amounts
• the only abnormality seen in older embryos
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kinked tail
(
J:31524
)
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• varying degrees
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thick tail
(
J:31524
)
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• degree of thickness varies
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reproductive system
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• litters from carrier males and normal females are reduced compared to normal; litters from matings of carrier females and normal males are even smaller in size
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homeostasis/metabolism
growth/size/body
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• characteristic of mice inheriting the Thp allele from their father
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embryo
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• at E10 the neural tube of the tail region is often doubled or tripled in embryos inheriting the Thp allele from their mother
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• characteristic of some E10 embryos inheriting the Thp allele from their father
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spina bifida
(
J:31524
)
|
• occurs at a low frequency among embryos inheriting the Thp allele from their mother
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• at E10 the notochord in the trunk is poorly differentiated and characteristic of embryos inheriting the Thp allele from their father
• at E10 the notochord in the tail may be absent, swollen, or duplicated in embryos inheriting the Thp allele from their father
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• at E10 the tail notochord may be absent in embryos inheriting the Thp allele from their father
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cardiovascular system
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• inflation of the pericardium is seen in embryos inheriting the Thp allele from their mother
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nervous system
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• at E10 the neural tube of the tail region is often doubled or tripled in embryos inheriting the Thp allele from their mother
|
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• characteristic of some E10 embryos inheriting the Thp allele from their father
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spina bifida
(
J:31524
)
|
• occurs at a low frequency among embryos inheriting the Thp allele from their mother
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exencephaly
(
J:31524
)
|
• occurs in low frequency among embryos inheriting the Thp allele from their mother
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skeleton
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• may end abruptly before or at the level of the second sacral vertebra
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• characteristic of embryos inheriting the Thp allele from their father
• one or more may be incomplete dorsally
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• characteristic of embryos inheriting the Thp allele from their father
• frequently incomplete dorsally
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• characteristic of embryos inheriting the Thp allele from their father
• frequently incomplete dorsally
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cellular
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• heterozygous offspring from carrier females and normal males are edematous and die before or at birth
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