Map3k4^C57BL/6J
Allele Detail

Summary

• Symbol: Map3k4^C57BL/6J
• Name: mitogen-activated protein kinase kinase kinase 4; T-associated sex reversal, C57BL/6J
• MGI ID: MGI:1856634
• Synonyms: Map3k4^Tas, Tas, T-associated sex reversal
• Gene: Map3k4 Location: Chr17:12446508-12537683 bp, - strand Genetic Position: Chr17, 8.42 cM
• Alliance: Map3k4^C57BL/6J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Not Applicable
• Mutation: Deletion
• Map3k4^C57BL/6J involves 13 genes/genome features (T, Pde10a, Gm15425 ...) View all
• Mutation details: The Map3k4 gene is located in a deletion extending from T, brachyury, to and including the Qk locus. Haploinsufficiency for Map3k4^C57BL/6J in a specific genetic (C57BL/6J) background accounts for the T-associated sex reversal (Tas) phenotype. (J:10943, J:153050)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k4 Mutation: 77 strains or lines available

References

• Original: J:7073 Washburn LL, et al., Sex reversal in XY mice caused by dominant mutation on chromosome 17. Nature. 1983 May 26;303(5915):338-40
• All: 7 reference(s)