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Pde10a Gene Detail
Summary
  • Symbol
    Pde10a
  • Name
    phosphodiesterase 10A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345143
    NCBI Gene: 23984
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:8744204-9205480 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 4.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10623 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345143
 protein coding gene Chr17:8742719-9205480 (+)
129S1/SvImJ ENSMUSG00200033233
 protein coding gene Chr17:4979350-5434184 (+)
A/J ENSMUSG00195023064
 protein coding gene Chr17:5187698-5649521 (+)
AKR/J ENSMUSG00220025580
 protein coding gene Chr17:5252858-5711549 (+)
BALB/cJ ENSMUSG00180021692
 protein coding gene Chr17:4833884-5295685 (+)
C3H/HeJ ENSMUSG00175031252
 protein coding gene Chr17:4978165-5439929 (+)
C57BL/6NJ ENSMUSG00215025731
 protein coding gene Chr17:4986537-5448117 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021060
 protein coding gene Chr17:7899206-8345966 (-)
CAST/EiJ ENSTCUG00005021960
 protein coding gene Chr17:5226397-5684003 (+)
CBA/J ENSMUSG00210035051
 protein coding gene Chr17:4644965-5106722 (+)
DBA/2J ENSMUSG00185022218
 protein coding gene Chr17:5737651-6199399 (+)
FVB/NJ ENSMUSG00205008437
 protein coding gene Chr17:5050740-5512177 (+)
JF1/MsJ ENSUMUG00000017124
 protein coding gene Chr17:5339805-5789655 (+)
LP/J ENSMUSG00230032200
 protein coding gene Chr17:7173151-7631763 (+)
NOD/ShiLtJ ENSMUSG00190031887
 protein coding gene Chr17:5183356-5645084 (+)
NZO/HlLtJ ENSMUSG00225029012
 protein coding gene Chr17:9093445-9552052 (+)
PWK/PhJ ENSLUMG00010018577
 protein coding gene Chr17:5153191-5611598 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005013613
 protein coding gene Chr17:5039090-5500278 (+)



Homology
more
  • Human Ortholog
    PDE10A, phosphodiesterase 10A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE10A, phosphodiesterase 10A
  • Synonyms
    ADSD2, HSPDE10A, IOLOD, PDE10A19
  • Links
    NCBI Gene ID: 10846
    UniProt: Q9Y233

  • Chr Location
    6q27; chr6:165327287-165988117 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PDE10A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 6 alleles in 6 genetic backgrounds
    408 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in decreased exploratory behavior, hypoactivity, and a delay in the acquisition of conditioned avoidance behavior. A hypomorphic allele results in increased social behavior. Mice homozygous for a knock-out allele exhibit resistance to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    853
  • Tissues
    130
  • cDNA Data
    45
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023868 Ensembl Gene Model | MGI Sequence Detail 461277 C57BL/6J ±  kb
    transcript ENSMUST00000115724 Ensembl | MGI Sequence Detail 3611 Not Applicable  
    polypeptide ENSMUSP00000111389 Ensembl | MGI Sequence Detail 850 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000012463 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
      (term hierarchy)
    • EC
      3.1.4.-, 3.1.4.17
    • InterPro Domains
      IPR023088 3'5'-cyclic nucleotide phosphodiesterase
      IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
      IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
      IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
      IPR003018 GAF domain
      IPR029016 GAF-like domain superfamily
      IPR003607 HD/PDEase domain
    • GlyGen
      Q8CA95 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 46
      Primer pair 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 466
      Developmental Gene Expression 7
      Diseases 6
      Gene Ontology 15
      Phenotypes 408
    • Earliest
      J:7073 Washburn LL, et al., Sex reversal in XY mice caused by dominant mutation on chromosome 17. Nature. 1983 May 26;303(5915):338-40
    • Latest
      J:391449 Thibodeau J, et al., Loss of cystathionine-beta-synthase contributes to elevated OXPHOS, a vulnerability in Ara-C-resistant Myeloid Leukemia in Down syndrome. Biochem Pharmacol. 2026 Feb 13;247:117815
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory