Phenotypes associated with this allele

• Allele Symbol: Cbx7^tm1Afus
• Allele Name: targeted mutation 1, Alfredo Fusco
• Allele ID: MGI:5427591
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cbx7^tm1Afus/Cbx7^tm1Afus	involves: C57BL/6J	MGI:5427600
ht2	Cbx7^tm1Afus/Cbx7^+	involves: C57BL/6J	MGI:5427601

Genotype
MGI:5427600

hm1

• Allelic Composition: Cbx7^tm1Afus/Cbx7^tm1Afus
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increased body length of Cbx7^tm1Afus/Cbx7^tm1Afus mice

growth/size/body

increased body length ( J:184383 )

• significantly increased naso-anal body length (6.5% for females and 16% for males)

cellular

abnormal cell cycle ( J:184383 )

• fewer cells in G1 and more in the S stage

abnormal cell death ( J:184383 )

• reduced level of MEF cell senescence

increased fibroblast proliferation ( J:184383 )

• E12.5 MEFs grow considerably faster than control mouse MEFs

neoplasm

increased tumor incidence ( J:184383 )

• solid tumors are present in 17-22 month old mice

• mice appear healthy through 12 months of age

increased liver tumor incidence ( J:184383 )

increased hepatocellular carcinoma incidence ( J:184383 )

• in 32% of homozygous livers

• an equal number of liver lesions are benign

increased liver adenoma incidence ( J:184383 )

increased carcinoma incidence ( J:184383 )

increased lung tumor incidence ( J:184383 )

increased lung carcinoma incidence ( J:184383 )

• the prevalent tumor type in lungs

respiratory system

increased lung tumor incidence ( J:184383 )

increased lung carcinoma incidence ( J:184383 )

• the prevalent tumor type in lungs

liver/biliary system

increased liver tumor incidence ( J:184383 )

increased hepatocellular carcinoma incidence ( J:184383 )

• in 32% of homozygous livers

• an equal number of liver lesions are benign

increased liver adenoma incidence ( J:184383 )

Genotype
MGI:5427601

ht2

• Allelic Composition: Cbx7^tm1Afus/Cbx7⁺
• Genetic Background: involves: C57BL/6J

Liver and lung neoplasias in Cbx7^tm1Afus/Cbx7^tm1Afus and Cbx7^tm1Afus/Cbx7⁺ mice

neoplasm

increased hepatocellular carcinoma incidence ( J:184383 )

• in 14% of heterozygotes

increased liver adenoma incidence ( J:184383 )

increased lung adenoma incidence ( J:184383 )

• lung adenomas only in heterozygotes

respiratory system

increased lung adenoma incidence ( J:184383 )

• lung adenomas only in heterozygotes

liver/biliary system

increased hepatocellular carcinoma incidence ( J:184383 )

• in 14% of heterozygotes

increased liver adenoma incidence ( J:184383 )