Cbx7^tm1Afus
Targeted Allele Detail

Summary

• Symbol: Cbx7^tm1Afus
• Name: chromobox 7; targeted mutation 1, Alfredo Fusco
• MGI ID: MGI:5427591
• Gene: Cbx7 Location: Chr15:79800008-79855320 bp, - strand Genetic Position: Chr15, 37.85 cM
• Alliance: Cbx7^tm1Afus page

Increased body length of Cbx7^tm1Afus/Cbx7^tm1Afus mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184383
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 5 and 6 were replaced with a neomycin selection cassette. Northern blot analysis demonstrated the absence of full length mRNA and Western blot analysis failed to indicated the presence of a protein product. (J:184383)

Generation of the Cbx7^tm1Afus allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cbx7^tm1Afus

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbx7 Mutation: 233 strains or lines available

References

• Original: J:184383 Forzati F, et al., CBX7 is a tumor suppressor in mice and humans. J Clin Invest. 2012 Feb 1;122(2):612-23
• All: 2 reference(s)