All Phenotypes Nr1h3<tm1.1Djm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ldlr^tm1Her/Ldlr^tm1Her Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA	MGI:5427004
cn2	Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S/SvEv * C57BL/6 * DBA	MGI:5427002

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Atherosclerosis lesion area is increased in Ldlr^tm1Her/Ldlr^tm1Her Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice and TO901317 treatment reduces these lesions

homeostasis/metabolism

decreased circulating triglyceride level ( J:184536 )

• by 4 weeks in mice fed a western diet

abnormal cholesterol homeostasis ( J:184536 )

• mice fed a western diet and treated with T0901317 (an Lxr/Nr1h3 agonist) exhibit impaired reverse cholesterol transport compared with control mice

decreased circulating cholesterol level ( J:184536 )

• by 4 weeks in mice fed a western diet

increased liver cholesterol level ( J:184536 )

• in mice fed a western diet at the conclusion of the experiment

decreased physiological sensitivity to xenobiotic ( J:184536 )

• mice fed a western diet and treated with T0901317 (an Lxr/Nr1h3 agonist) fail to exhibit a change in plasma lipid levels or an increase in fecal excretion of macrophage-derived sterols but an increase in hepatic sterols compared with control mice

• however, treatment with T0901317 reduces atherosclerosis as in controls

liver/biliary system

increased liver cholesterol level ( J:184536 )

• in mice fed a western diet at the conclusion of the experiment

cardiovascular system

increased susceptibility to atherosclerosis ( J:184536 )

• mice fed a western diet exhibit increase in lesion size as detected by macrophage staining compared with control mice

• however, collagen staining or lesions is normal and treatment with T0901317 reduces atherosclerosis as in controls

Allelic Composition	Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129S/SvEv * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1h3^tm1.1Djm mutation (1 available); any Nr1h3 mutation (32 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:184536 )

• mice treated with T0901317 (an Lxr/Nr1h3 agonist) exhibit an attenuated increase in plasma triglycerides, hepatic triglycerides, biliary cholesterol, biliary cholesterol secretion and fecal neutral sterols but an attenuated decrease in CAMCA bile acid composition and cholesterol absorption compared with control mice

increased liver cholesterol level ( J:184536 )

• in mice fed a 2% cholesterol diet

decreased physiological sensitivity to xenobiotic ( J:184536 )

• mice treated with T0901317 (an Lxr/Nr1h3 agonist) exhibit an attenuated increase in plasma triglycerides and cholesterol, hepatic triglycerides, biliary cholesterol, biliary cholesterol secretion and fecal neutral sterols and attenuated decrease in CAMCA bile acid composition, cholesterol absorption and hepatic cholesterol compared with control mice

liver/biliary system

increased liver weight ( J:184536 )

• in mice fed a 2% cholesterol diet

increased liver cholesterol level ( J:184536 )

• in mice fed a 2% cholesterol diet

growth/size/body

increased liver weight ( J:184536 )

• in mice fed a 2% cholesterol diet

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