Phenotypes associated with this allele
Allelic Composition |
Xpatm1Gvh/Xpatm1Hvs
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Genetic Background |
involves: 129P2/OlaHsd * C57BL/6J |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xpatm1Gvh mutation
(0 available);
any
Xpa mutation
(22 available)
Xpatm1Hvs mutation
(4 available);
any
Xpa mutation
(22 available)
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cellular
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• mouse embryonic fibroblasts are resistant to UV irradiation compared with control mice
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Neurodegenerative changes in Ercc6tm1Gvh/Ercc6tm1Gvh Xpatm1Gvh/Xpatm1Hvs Tg(Pcp2-cre)2Mpin/0 mice
nervous system
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• argyrophilic axonal degeneration in the cerebellar white matter and cerebellar nuclei
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immune system
hematopoietic system
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre)13Miya mutation
(1 available)
Xpatm1Gvh mutation
(0 available);
any
Xpa mutation
(22 available)
Xpatm1Hvs mutation
(4 available);
any
Xpa mutation
(22 available)
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cellular
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• in mouse embryonic fibroblasts
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Ercc6tm1Gvh/Ercc6tm1Gvh Xpatm1Gvh/Xpatm1Hvs Tg(CAG-cre)13Miya/0 mice are severely reduced in size
mortality/aging
behavior/neurological
growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc6tm1Gvh mutation
(1 available);
any
Ercc6 mutation
(78 available)
Tg(Camk2a-cre)1Szi mutation
(0 available)
Xpatm1Gvh mutation
(0 available);
any
Xpa mutation
(22 available)
Xpatm1Hvs mutation
(4 available);
any
Xpa mutation
(22 available)
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Dilated ventricles and brain atrophy in Ercc6tm1Gvh/Ercc6tm1Gvh Xpatm1Gvh/Xpatm1Hvs Tg(Camk2a-cre)1Szi/0 mice
mortality/aging
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• between 12 and 22 months
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nervous system
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• from 9 to 12 months of age, mice exhibit seizure behavior characterized by episodes of immobility unlike control mice
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• at 6 to 12 months of age, mice exhibit atrophy in the telencephalon (cortex, hippocampus, caudate-putamen and septum) unlike control mice
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• atrophic at 6 to 12 months of age
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• atrophic at 6 to 12 months of age
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• mild atrophy at 6 months of age
• severe atrophy in older mice
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• at 6 to 12 months of age
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behavior/neurological
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• from 9 to 12 months of age, mice exhibit seizure behavior characterized by episodes of immobility unlike control mice
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growth/size/body
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• at 9 to 12 months of age
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• at 9 to 12 months of age
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immune system
hematopoietic system