Phenotype Image Detail

Image

Caption

D, E) Coronal 4 um thick, haematoxylin/eosin-stained paraffin sections of 15 and 65 week old Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0 (Xpa^c/- CamKIIa-Cre) and Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0 (Csb^-/- Xpa^c/- CamKIIa-Cre) mouse brains; sections grossly correspond to sections 0.5 to 1 mm anterior to the bregma (D) and 1.5 to 2 mm posterior to the bregma (E) as depicted in the mouse brain atlas of Paxinos and Franklin. 65 week old Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0 show dilated ventricles, and atrophy of the neocortex (NCx), hippocampus, the caudatus-putamen (CPu) and the septum. CA3, CA3 hippocampal subfields; DG, dentate gyrus; Th, thalamus; LS, lateral septum; lv, lateral ventricle. F) GFAP-immunoperoxidase staining in coronal brain sections of 65 week-old Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0 (Xpa^c/- CamKIIa-Cre), Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Gvh/Xpa^tm1Hvs (Csb^-/- Xpa^c/-), and Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0 (Csb^-/- Xpa^c/- CamKIIa-Cre) shows increased GFAP staining in the neocortex (NCX), hippocampus and amygdala of Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0 (Csb^-/^-Xpac/^-CamKIIa-Cre) mice. GFAP staining in the thalamus (Th) was the same as in Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0 and Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Gvh/Xpa^tm1Hvs mice.

This image is from Jaarsma D, PLoS Genet 2011 Dec;7(12):e1002405, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:179808

Associated
Alleles

Symbol	Name
Ercc6^tm1Gvh	excision repair cross-complementing rodent repair deficiency, complementation group 6; targeted mutation 1, Gijsbertus van der Horst
Tg(Camk2a-cre)1Szi	transgene insertion 1, Scott Zeitlin
Xpa^tm1Gvh	xeroderma pigmentosum, complementation group A; targeted mutation 1, Gijsbertus T J van der Horst
Xpa^tm1Hvs	xeroderma pigmentosum, complementation group A; targeted mutation 1, Harry van Steeg

Associated
Genotypes

Allelic Composition	Genetic Background
Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0	involves: 129P2/OlaHsd * C57BL/6J * CBA

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