Analysis Tools|
Allele Symbol Allele Name Allele ID |
Pitx2tm1.1Dmm targeted mutation 1.1, Donna M Martin MGI:5308807 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• abdominal viscera defects similar to in Pitx2tm2Sac homozygotes
|
|
• distal turning defect similar to in Pitx2tm2Sac homozygotes
|
|
• similar to in Pitx2tm2Sac homozygotes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• abdominal and abdominal viscera defects similar to in Pitx2tm2Sac homozygotes
|
|
• distal turning defect similar to in Pitx2tm2Sac homozygotes
|
|
• mice lack migration of subthalamic neurons and recruitment of their projections into an expanded mammillotegmental tract
|
|
• mice lack migration of subthalamic neurons and recruitment of their projections into an expanded mammillotegmental tract
|
|
• similar to in Pitx2tm2Sac homozygotes
|
|
• medially displaced
|
|
• severe
|
|
• mice lack migration of subthalamic neurons and recruitment of their projections into an expanded mammillotegmental tract
|
|
• severe
|
|
• severe
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mammillothalamic tract fibers are truncated or severely diminished compared to in control mice
• PAX6+ cells at the principal mammillary tract-mammillothalamic tract bifurcation are reduced compared to in control mice
• however, mice exhibit intact principal mammillary and mammillotegmental projections
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/30/2025 MGI 6.24 |
|
|
|
||
