About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pitx2tm1.1Dmm
targeted mutation 1.1, Donna M Martin
MGI:5308807
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pitx2tm1.1Dmm/Pitx2tm1.1Dmm B6.129P2-Pitx2tm1.1Dmm MGI:5308809
ht2
 		Pitx2tm1.1Dmm/Pitx2tm2Sac involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5308808
cn3
 		Pitx2tm1.1Dmm/Pitx2tm1.1Sac
Tg(Nes-cre)1Kln/0 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5308810


Genotype
MGI:5308809
hm1
Allelic
Composition		 Pitx2tm1.1Dmm/Pitx2tm1.1Dmm
Genetic
Background		 B6.129P2-Pitx2tm1.1Dmm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pitx2tm1.1Dmm mutation (1 available); any Pitx2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo development ( J:181058 )
• abdominal viscera defects similar to in Pitx2tm2Sac homozygotes
abnormal embryo turning ( J:181058 )
• distal turning defect similar to in Pitx2tm2Sac homozygotes

cardiovascular system
abnormal heart morphology ( J:181058 )
• similar to in Pitx2tm2Sac homozygotes




Genotype
MGI:5308808
ht2
Allelic
Composition		 Pitx2tm1.1Dmm/Pitx2tm2Sac
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pitx2tm1.1Dmm mutation (1 available); any Pitx2 mutation (38 available)
Pitx2tm2Sac mutation (0 available); any Pitx2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo development ( J:181058 )
• abdominal and abdominal viscera defects similar to in Pitx2tm2Sac homozygotes
abnormal embryo turning ( J:181058 )
• distal turning defect similar to in Pitx2tm2Sac homozygotes

nervous system
abnormal neuronal migration ( J:181058 )
• mice lack migration of subthalamic neurons and recruitment of their projections into an expanded mammillotegmental tract
abnormal nervous system tract morphology ( J:181058 )
• mice lack migration of subthalamic neurons and recruitment of their projections into an expanded mammillotegmental tract

cardiovascular system
abnormal heart morphology ( J:181058 )
• similar to in Pitx2tm2Sac homozygotes

vision/eye
abnormal eye distance/ position ( J:181058 )
• medially displaced

craniofacial

cellular
abnormal neuronal migration ( J:181058 )
• mice lack migration of subthalamic neurons and recruitment of their projections into an expanded mammillotegmental tract

endocrine/exocrine glands

growth/size/body
abnormal tooth morphology ( J:181058 )
• severe

skeleton




Genotype
MGI:5308810
cn3
Allelic
Composition		 Pitx2tm1.1Dmm/Pitx2tm1.1Sac
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pitx2tm1.1Dmm mutation (1 available); any Pitx2 mutation (38 available)
Pitx2tm1.1Sac mutation (1 available); any Pitx2 mutation (38 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system tract morphology ( J:181058 )
• mammillothalamic tract fibers are truncated or severely diminished compared to in control mice
• PAX6+ cells at the principal mammillary tract-mammillothalamic tract bifurcation are reduced compared to in control mice
• however, mice exhibit intact principal mammillary and mammillotegmental projections




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory