Pitx2^tm1.1Dmm
Targeted Allele Detail

Summary

• Symbol: Pitx2^tm1.1Dmm
• Name: paired-like homeodomain transcription factor 2; targeted mutation 1.1, Donna M Martin
• MGI ID: MGI:5308807
• Synonyms: Pitx2^Taulacz, Pitx2^tlz
• Gene: Pitx2 Location: Chr3:128993527-129013240 bp, + strand Genetic Position: Chr3, 57.84 cM
• Alliance: Pitx2^tm1.1Dmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181058
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a splice acceptor, stop codon, IRES, bovine MAPT fused to lacZ (tau-lacZ) and floxed neo cassette. Cre-mediated recombination removed the neo cassette. Immunofluorescence confirmed the absence of protein expression. (J:181058)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pitx2 Mutation: 38 strains or lines available

References

• Original: J:181058 Skidmore JM, et al., A novel TaulacZ allele reveals a requirement for Pitx2 in formation of the mammillothalamic tract. Genesis. 2012 Jan;50(1):67-73
• All: 3 reference(s)