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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dll4tm2.1Vlcg
targeted mutation 2.1, Velocigene
MGI:5302387
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dll4tm2.1Vlcg/Dll4tm2.1Vlcg involves: 129S6/SvEvTac * C57BL/6NTac MGI:5546215
cn2
 		Dll4tm2.1Vlcg/Dll4+
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac MGI:5302388
cn3
 		Dll4tm2.1Vlcg/Dll4+
Tg(Nanog-cre)#Vlcg/0 		involves: 129S6/SvEvTac * C57BL/6NTac MGI:5546216
cn4
 		Dll4tm2.1Vlcg/Dll4tm2.1Vlcg
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+ 		involves: 129S6/SvEvTac * C57BL/6NTac MGI:5546217


Genotype
MGI:5546215
hm1
Allelic
Composition		 Dll4tm2.1Vlcg/Dll4tm2.1Vlcg
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4tm2.1Vlcg mutation (0 available); any Dll4 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5302388
cn2
Allelic
Composition		 Dll4tm2.1Vlcg/Dll4+
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4tm2.1Vlcg mutation (0 available); any Dll4 mutation (26 available)
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal induced retina neovascularization ( J:177797 )
• retinal capillaries from tamoxifen-treated mice are more resistant to oxygen-induced vaso-obliteration compared with control capillaries
abnormal vascular regression ( J:177797 )
• tamoxifen-treated mice exhibit reduced capillary regression during normal developmental capillary remodeling compared with control mice

vision/eye
abnormal induced retina neovascularization ( J:177797 )
• retinal capillaries from tamoxifen-treated mice are more resistant to oxygen-induced vaso-obliteration compared with control capillaries

cellular
abnormal vascular regression ( J:177797 )
• tamoxifen-treated mice exhibit reduced capillary regression during normal developmental capillary remodeling compared with control mice




Genotype
MGI:5546216
cn3
Allelic
Composition		 Dll4tm2.1Vlcg/Dll4+
Tg(Nanog-cre)#Vlcg/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4tm2.1Vlcg mutation (0 available); any Dll4 mutation (26 available)
Tg(Nanog-cre)#Vlcg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal angiogenesis ( J:200671 )
• severe as in Dll4tm1Nwg heterozygotes

embryo
abnormal embryo development ( J:200671 )
• authors state that mice phenocopy Dll4tm1Nwg heterozygotes




Genotype
MGI:5546217
cn4
Allelic
Composition		 Dll4tm2.1Vlcg/Dll4tm2.1Vlcg
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4tm2.1Vlcg mutation (0 available); any Dll4 mutation (26 available)
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:200671 )
• abrogated maturation in mice treated with tamoxifen at P5

vision/eye
abnormal retina vasculature morphology ( J:200671 )
• abrogated maturation in mice treated with tamoxifen at P5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory