All Phenotypes Rest<tm1.1Jhsi> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rest^tm1.1Jhsi/Rest^tm1.1Jhsi	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:5141117
cn2	Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Rest^tm1.1Jhsi/Rest^tm1.1Jhsi Tg(Nes-cre/ERT2)KEisc/0	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL	MGI:5141116
cn3	Rest^tm1.1Jhsi/Rest^tm1.1Jhsi Tg(CAG-cre)13Miya/0	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:5141115

Allelic Composition	Rest^tm1.1Jhsi/Rest^tm1.1Jhsi
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rest^tm1.1Jhsi mutation (1 available); any Rest mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:174056 )

• neurospheres treated with cre-expressing adenovirus exhibit reduced self-renewal capacity compared with wild-type cells

cellular

abnormal neuron differentiation ( J:174056 )

• neurospheres treated with cre-expressing adenovirus exhibit reduced self-renewal capacity compared with wild-type cells

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:174056 )

• 20 days after tamoxifen treatment, mice exhibit a transient increase in hippocampal neurogenesis compared with control mice

• tamoxifen-treatment increased hippocampal neurogenesis in vitro and in vivo compared with controls

• tamoxifen-treated mice exhibit premature exit of quiescence compared with control mice

• tamoxifen-treated mice exhibit loss of neurogenic capacity of adult neurospheres and decreased neurogenesis over time compared with control mice

• neurospheres treated from tamoxifen-treated mice exhibit reduced self-renewal capacity compared with wild-type cells

• however, hippocampal neurogenesis is normal 10 and 30 days after tamoxifen treatment

premature neuronal precursor differentiation ( J:174056 )

• in tamoxifen-treated mice

decreased neuron number ( J:174056 )

• tamoxifen-treated mice exhibit decreased adult-generated immature and mature granule neurons compared with control mice

cellular

abnormal neuron differentiation ( J:174056 )

• 20 days after tamoxifen treatment, mice exhibit a transient increase in hippocampal neurogenesis compared with control mice

• tamoxifen-treatment increased hippocampal neurogenesis in vitro and in vivo compared with controls

• tamoxifen-treated mice exhibit premature exit of quiescence compared with control mice

• tamoxifen-treated mice exhibit loss of neurogenic capacity of adult neurospheres and decreased neurogenesis over time compared with control mice

• neurospheres treated from tamoxifen-treated mice exhibit reduced self-renewal capacity compared with wild-type cells

• however, hippocampal neurogenesis is normal 10 and 30 days after tamoxifen treatment

premature neuronal precursor differentiation ( J:174056 )

• in tamoxifen-treated mice

Allelic Composition	Rest^tm1.1Jhsi/Rest^tm1.1Jhsi Tg(CAG-cre)13Miya/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rest^tm1.1Jhsi mutation (1 available); any Rest mutation (95 available)
Tg(CAG-cre)13Miya mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:174056 )

• mice exhibit the same embryonic lethality phenotype as Rest^tm1And homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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