Phenotypes associated with this allele

• Allele Symbol: Sik3^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5085429
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sik3^tm1a(EUCOMM)Hmgu/Sik3^tm1a(EUCOMM)Hmgu	C57BL/6N-Sik3^tm1a(EUCOMM)Hmgu/Wtsi	MGI:6263474

Genotype
MGI:6263474

hm1

• Allelic Composition: Sik3^{tm1a(EUCOMM)Hmgu}/Sik3^{tm1a(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Sik3^{tm1a(EUCOMM)Hmgu}/Wtsi
• Cell Lines: HEPD0744_6_B02

Data Sources

IMPC Data for Sik3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

♂

IMPC - WTSI

craniofacial

abnormal cranium morphology ( J:211773 )

IMPC - WTSI

abnormal zygomatic bone morphology ( J:211773 )

♂

IMPC - WTSI

growth/size/body

abnormal zygomatic bone morphology ( J:211773 )

♂

IMPC - WTSI

increased lean body mass ( J:211773 )

♂

IMPC - WTSI

hematopoietic system

decreased erythrocyte cell number ( J:211773 )

♂

IMPC - WTSI

decreased hematocrit ( J:211773 )

♂

IMPC - WTSI

increased mean corpuscular hemoglobin ( J:211773 )

IMPC - WTSI

increased red blood cell distribution width ( J:211773 )

♂

IMPC - WTSI

increased granulocyte number ( J:211773 )

IMPC - WTSI

increased eosinophil cell number ( J:211773 )

IMPC - WTSI

thrombocytopenia ( J:211773 )

♂

IMPC - WTSI

increased mean platelet volume ( J:211773 )

♂

IMPC - WTSI

increased plasmacytoid dendritic cell number ( J:211773 )

IMPC - WTSI

decreased germinal center B cell number ( J:211773 )

IMPC - WTSI

decreased early germinal center B cell number ( J:211773 )

IMPC - WTSI

increased follicular B cell number ( J:211773 )

IMPC - WTSI

decreased NK cell number ( J:211773 )

♂

IMPC - WTSI

decreased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive mature NK cell number ( J:211773 )

IMPC - WTSI

increased NK cell number ( J:211773 )

IMPC - WTSI

increased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD8 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

increased Ly6C-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased KLRG1-positive T-helper cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive T-helper cell number ( J:211773 )

IMPC - WTSI

decreased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

increased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

increased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

decreased T cell number ( J:211773 )

♀

IMPC - WTSI

decreased NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased T-helper cell number ( J:211773 )

IMPC - WTSI

decreased gamma-delta T cell number ( J:211773 )

IMPC - WTSI

decreased CD5-positive gamma-delta T cell number ( J:211773 )

IMPC - WTSI

decreased regulatory T cell number ( J:211773 )

♂

IMPC - WTSI

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

IMPC - WTSI

decreased circulating fructosamine level ( J:211773 )

♂

IMPC - WTSI

decreased circulating glucose level ( J:211773 )

IMPC - WTSI

decreased circulating cholesterol level ( J:211773 )

♂

IMPC - WTSI

decreased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - WTSI

decreased circulating calcium level ( J:211773 )

♂

IMPC - WTSI

decreased circulating potassium level ( J:211773 )

♂

IMPC - WTSI

increased circulating sodium level ( J:211773 )

♂

IMPC - WTSI

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - WTSI

increased circulating amylase level ( J:211773 )

♀

IMPC - WTSI

decreased blood urea nitrogen level ( J:211773 )

IMPC - WTSI

improved glucose tolerance ( J:211773 )

♂

IMPC - WTSI

immune system

increased granulocyte number ( J:211773 )

IMPC - WTSI

increased eosinophil cell number ( J:211773 )

IMPC - WTSI

increased plasmacytoid dendritic cell number ( J:211773 )

IMPC - WTSI

decreased germinal center B cell number ( J:211773 )

IMPC - WTSI

decreased early germinal center B cell number ( J:211773 )

IMPC - WTSI

increased follicular B cell number ( J:211773 )

IMPC - WTSI

decreased NK cell number ( J:211773 )

♂

IMPC - WTSI

decreased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive mature NK cell number ( J:211773 )

IMPC - WTSI

increased NK cell number ( J:211773 )

IMPC - WTSI

increased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD8 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

increased Ly6C-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased KLRG1-positive T-helper cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive T-helper cell number ( J:211773 )

IMPC - WTSI

decreased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

increased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

increased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

decreased T cell number ( J:211773 )

♀

IMPC - WTSI

decreased NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased T-helper cell number ( J:211773 )

IMPC - WTSI

decreased gamma-delta T cell number ( J:211773 )

IMPC - WTSI

decreased CD5-positive gamma-delta T cell number ( J:211773 )

IMPC - WTSI

decreased regulatory T cell number ( J:211773 )

♂

IMPC - WTSI

integument

abnormal coat/hair pigmentation ( J:211773 )

IMPC - WTSI

limbs/digits/tail

abnormal humerus morphology ( J:211773 )

IMPC - WTSI

abnormal radius morphology ( J:211773 )

IMPC - WTSI

abnormal ulna morphology ( J:211773 )

IMPC - WTSI

abnormal femur morphology ( J:211773 )

IMPC - WTSI

abnormal fibula morphology ( J:211773 )

IMPC - WTSI

abnormal tibia morphology ( J:211773 )

IMPC - WTSI

abnormal tail morphology ( J:211773 )

IMPC - WTSI

pigmentation

abnormal coat/hair pigmentation ( J:211773 )

IMPC - WTSI

reproductive system

female infertility ( J:211773 )

♀

IMPC - WTSI

skeleton

abnormal cranium morphology ( J:211773 )

IMPC - WTSI

abnormal zygomatic bone morphology ( J:211773 )

♂

IMPC - WTSI

abnormal humerus morphology ( J:211773 )

IMPC - WTSI

abnormal radius morphology ( J:211773 )

IMPC - WTSI

abnormal ulna morphology ( J:211773 )

IMPC - WTSI

abnormal femur morphology ( J:211773 )

IMPC - WTSI

abnormal fibula morphology ( J:211773 )

IMPC - WTSI

abnormal tibia morphology ( J:211773 )

IMPC - WTSI

abnormal pelvic girdle bone morphology ( J:211773 )

IMPC - WTSI

abnormal rib morphology ( J:211773 )

IMPC - WTSI

abnormal thoracic cage shape ( J:211773 )

IMPC - WTSI

abnormal spine curvature ( J:211773 )

IMPC - WTSI

kyphosis ( J:211773 )

♂

IMPC - WTSI

abnormal vertebrae morphology ( J:211773 )

IMPC - WTSI

abnormal bone structure ( J:211773 )

IMPC - WTSI

abnormal joint morphology ( J:211773 )

IMPC - WTSI

vision/eye

abnormal cornea morphology ( J:211773 )

♀

IMPC - WTSI

abnormal retina morphology ( J:211773 )

♀

IMPC - WTSI