Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation
(14 available);
any
Lyz2 mutation
(41 available)
Pdcd10tm1Wami mutation
(0 available);
any
Pdcd10 mutation
(18 available)
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hematopoietic system
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• increased degranulation
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• increased degranulation
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homeostasis/metabolism
immune system
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• increased degranulation
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• increased degranulation
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renal/urinary system
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• after renal ischemia-reperfusion experiments
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cellular
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• after renal ischemia-reperfusion experiments
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation
(2 available);
any
Emx1 mutation
(34 available)
Pdcd10tm1Wami mutation
(0 available);
any
Pdcd10 mutation
(18 available)
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mortality/aging
N |
• mice exhibit normal survival to adulthood
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nervous system
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• 80% of mice 7 months or older develop vascular lesions in the forebrain unlike control mice
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• starting in early postnatal stages
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neoplasm
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• 80% of mice 7 months or older develop vascular lesions in the forebrain unlike control mice
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cardiovascular system
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• 80% of mice 7 months or older develop vascular lesions in the forebrain unlike control mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd10tm1Wami mutation
(0 available);
any
Pdcd10 mutation
(18 available)
Taglntm2(cre)Yec mutation
(1 available);
any
Tagln mutation
(26 available)
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mortality/aging
N |
• mice exhibit normal Mendelian ratio after weaning
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cardiovascular system
N |
• mice exhibit normal retinal vascular development
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd10tm1Wami mutation
(0 available);
any
Pdcd10 mutation
(18 available)
Tg(Tek-cre)12Flv mutation
(1 available)
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mortality/aging
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• normal Mendelian ratios cannot be detected after E9.5
• no mice are present after E10.5
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cardiovascular system
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• mice exhibit abnormal angiogenesis and remodeling in the telencephalic plexus compared with wild-type mice
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• intersomitic vessels are poorly organized and less branched compared to in wild-type mice
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• mice exhibit abnormal angiogenesis and remodeling in the yolk sac, telencephalic plexus, and intersomitic vasculature compared with wild-type mice
• angiogenesis is delayed compared to in wild-type mice
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• disorganized and discontinued
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• mice exhibit abnormal angiogenesis and remodeling in the yolk sac, telencephalic plexus, and intersomitic vasculature compared with wild-type mice
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• dilated, disorganized, and discontinued
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• mice exhibit abnormal angiogenesis and remodeling in the yolk sac compared with wild-type mice
• the yolk sac contains fewer blood vessels compared to in wild-type mice
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• the endocardium is dissociated from the myocardium unlike in wild-type mice
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• the endocardium is dissociated from the myocardium unlike in wild-type mice
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hematopoietic system
nervous system
N |
• neural tube closure is normal
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• mice exhibit abnormal angiogenesis and remodeling in the telencephalic plexus compared with wild-type mice
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embryo
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• mice exhibit abnormal angiogenesis and remodeling in the yolk sac compared with wild-type mice
• the yolk sac contains fewer blood vessels compared to in wild-type mice
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muscle
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• the endocardium is dissociated from the myocardium unlike in wild-type mice
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integument
growth/size/body
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd10tm1Wami mutation
(0 available);
any
Pdcd10 mutation
(18 available)
Tg(GFAP-cre)25Mes mutation
(2 available)
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mortality/aging
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• mice do not survive beyond 12 months of age
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• 80% of rate die by 4 weeks
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nervous system
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• abnormal cytoarchitecture
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• brain capillaries are dilated and less organized and dense than in control mice
• between 3 weeks and 12 months, two-thirds of mice develop cerebrovascular lesions resembling cavernomas unlike in control mice
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• starting in early postnatal stages
• astrocyte proliferation is increased compared to in control cells
• astrocytes exhibit resistance to cycloheximide-induced apoptosis compared with control cells
• retinal astrocyte spreading is decreased compared to in control mice
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cardiovascular system
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• brain capillaries are dilated and less organized and dense than in control mice
• between 3 weeks and 12 months, two-thirds of mice develop cerebrovascular lesions resembling cavernomas unlike in control mice
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• endothelial cell migration is delayed compared to in control mice
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neoplasm
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• between 3 weeks and 12 months, two-thirds of mice develop cerebrovascular lesions resembling cavernomas unlike in control mice
• mice develop cavernomas in the spinal cord unlike wild-type mice
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behavior/neurological
growth/size/body
cellular
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• endothelial cell migration is delayed compared to in control mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd10tm1Wami mutation
(0 available);
any
Pdcd10 mutation
(18 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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mortality/aging
N |
• mice exhibit normal Mendelian ratio after birth
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• mice do not survive past P3
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• fewer than expected mice are born
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nervous system
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• abnormal cytoarchitecture
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