About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rasal2Gt(463C12)Cmhd
gene trap 463C12, Centre for Modeling Human Disease
MGI:4960535
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl MGI:5554379
cx2
 		Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S * 129X1/SvJ * C57BL/6 * C57BL/6NCrl MGI:5554381
cx3
 		Rasal2Gt(463C12)Cmhd/Rasal2+
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S * 129X1/SvJ * C57BL/6 * C57BL/6NCrl MGI:5554383
cx4
 		Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd
Tg(MMTVneu)202Mul/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl * FVB/N MGI:5554380


Genotype
MGI:5554379
hm1
Allelic
Composition		 Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasal2Gt(463C12)Cmhd mutation (0 available); any Rasal2 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:202603 )
• overall survival is 77.8 weeks compared to 95.6 weeks for wild-type mice

neoplasm
decreased tumor latency ( J:202603 )
• however, tumor spectrum is the same as in wild-type mice




Genotype
MGI:5554381
cx2
Allelic
Composition		 Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S * 129X1/SvJ * C57BL/6 * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasal2Gt(463C12)Cmhd mutation (0 available); any Rasal2 mutation (61 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (238 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:202603 )
• mice typically die from the primary tumor, frequently lymphoma

neoplasm
increased mouth tumor incidence ( J:202603 )
• oral tumors unlike in Trp53tm1Tyj homozygotes
increased colon adenoma incidence ( J:202603 )
• unlike in Trp53tm1Tyj homozygotes
increased stomach tumor incidence ( J:202603 )
• unlike in Trp53tm1Tyj homozygotes
increased liver tumor incidence ( J:202603 )
• unlike in Trp53tm1Tyj homozygotes
increased hepatocellular carcinoma incidence ( J:202603 )
• unlike in Trp53tm1Tyj homozygotes
increased metastatic potential ( J:202603 )
• highly metastatic mammary adenocarcinomas, hepatocellular carcinomas, lung adenocarcinomas and various sarcomas compared to in Trp53tm1Tyj homozygotes
increased lymphoma incidence ( J:202603 )
• lymphomas resulting in death as in Trp53tm1Tyj homozygotes

digestive/alimentary system
increased colon adenoma incidence ( J:202603 )
• unlike in Trp53tm1Tyj homozygotes
increased stomach tumor incidence ( J:202603 )
• unlike in Trp53tm1Tyj homozygotes

liver/biliary system
increased liver tumor incidence ( J:202603 )
• unlike in Trp53tm1Tyj homozygotes
increased hepatocellular carcinoma incidence ( J:202603 )
• unlike in Trp53tm1Tyj homozygotes

craniofacial
increased mouth tumor incidence ( J:202603 )
• oral tumors unlike in Trp53tm1Tyj homozygotes

growth/size/body
increased mouth tumor incidence ( J:202603 )
• oral tumors unlike in Trp53tm1Tyj homozygotes




Genotype
MGI:5554383
cx3
Allelic
Composition		 Rasal2Gt(463C12)Cmhd/Rasal2+
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S * 129X1/SvJ * C57BL/6 * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasal2Gt(463C12)Cmhd mutation (0 available); any Rasal2 mutation (61 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (238 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased metastatic potential ( J:202603 )
• highly metastatic mammary adenocarcinomas, hepatocellular carcinomas, lung adenocarcinomas and various sarcomas compared to in Trp53tm1Tyj homozygotes




Genotype
MGI:5554380
cx4
Allelic
Composition		 Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd
Tg(MMTVneu)202Mul/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasal2Gt(463C12)Cmhd mutation (0 available); any Rasal2 mutation (61 available)
Tg(MMTVneu)202Mul mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:202603 )
• at the same frequency as in Tg(MMTVneu)202Mul mice
increased metastatic potential ( J:202603 )
• increased metastasis to additional organs compared with Tg(MMTVneu)202Mul mice

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:202603 )
• at the same frequency as in Tg(MMTVneu)202Mul mice

integument
increased mammary adenocarcinoma incidence ( J:202603 )
• at the same frequency as in Tg(MMTVneu)202Mul mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory