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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rasal2Gt(463C12)Cmhd
gene trap 463C12, Centre for Modeling Human Disease
MGI:4960535
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl MGI:5554379
cx2
 		Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S * 129X1/SvJ * C57BL/6 * C57BL/6NCrl MGI:5554381
cx3
 		Rasal2Gt(463C12)Cmhd/Rasal2+
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S * 129X1/SvJ * C57BL/6 * C57BL/6NCrl MGI:5554383
cx4
 		Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd
Tg(MMTVneu)202Mul/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl * FVB/N MGI:5554380


Genotype
MGI:5554379
hm1
Allelic
Composition		 Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasal2Gt(463C12)Cmhd mutation (0 available); any Rasal2 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:202603 )
• overall survival is 77.8 weeks compared to 95.6 weeks for wild-type mice

neoplasm
decreased tumor latency ( J:202603 )
• however, tumor spectrum is the same as in wild-type mice




Genotype
MGI:5554381
cx2
Allelic
Composition		 Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S * 129X1/SvJ * C57BL/6 * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasal2Gt(463C12)Cmhd mutation (0 available); any Rasal2 mutation (59 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:202603 )
• mice typically die from the primary tumor, frequently lymphoma

neoplasm
increased colon adenoma incidence ( J:202603 )
• unlike in Trp53tm1Tyj homozygotes
increased stomach tumor incidence ( J:202603 )
• unlike in Trp53tm1Tyj homozygotes
increased mouth tumor incidence ( J:202603 )
• oral tumors unlike in Trp53tm1Tyj homozygotes
increased liver tumor incidence ( J:202603 )
• unlike in Trp53tm1Tyj homozygotes
increased hepatocellular carcinoma incidence ( J:202603 )
• unlike in Trp53tm1Tyj homozygotes
increased metastatic potential ( J:202603 )
• highly metastatic mammary adenocarcinomas, hepatocellular carcinomas, lung adenocarcinomas and various sarcomas compared to in Trp53tm1Tyj homozygotes
increased lymphoma incidence ( J:202603 )
• lymphomas resulting in death as in Trp53tm1Tyj homozygotes

digestive/alimentary system
increased colon adenoma incidence ( J:202603 )
• unlike in Trp53tm1Tyj homozygotes
increased stomach tumor incidence ( J:202603 )
• unlike in Trp53tm1Tyj homozygotes
increased mouth tumor incidence ( J:202603 )
• oral tumors unlike in Trp53tm1Tyj homozygotes

liver/biliary system
increased liver tumor incidence ( J:202603 )
• unlike in Trp53tm1Tyj homozygotes
increased hepatocellular carcinoma incidence ( J:202603 )
• unlike in Trp53tm1Tyj homozygotes




Genotype
MGI:5554383
cx3
Allelic
Composition		 Rasal2Gt(463C12)Cmhd/Rasal2+
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S * 129X1/SvJ * C57BL/6 * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasal2Gt(463C12)Cmhd mutation (0 available); any Rasal2 mutation (59 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased metastatic potential ( J:202603 )
• highly metastatic mammary adenocarcinomas, hepatocellular carcinomas, lung adenocarcinomas and various sarcomas compared to in Trp53tm1Tyj homozygotes




Genotype
MGI:5554380
cx4
Allelic
Composition		 Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd
Tg(MMTVneu)202Mul/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasal2Gt(463C12)Cmhd mutation (0 available); any Rasal2 mutation (59 available)
Tg(MMTVneu)202Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:202603 )
• at the same frequency as in Tg(MMTVneu)202Mul mice
increased metastatic potential ( J:202603 )
• increased metastasis to additional organs compared with Tg(MMTVneu)202Mul mice

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:202603 )
• at the same frequency as in Tg(MMTVneu)202Mul mice

integument
increased mammary adenocarcinoma incidence ( J:202603 )
• at the same frequency as in Tg(MMTVneu)202Mul mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory