|
Allele Symbol Allele Name Allele ID |
Ppp2catm1.1Nju targeted mutation 1.1, Model Animal Research Center of Nanjing University MGI:4950915 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• a further loss of mice is seen between E12.5 and E14.5
• however, some mice survive to adulthood
|
|
• the expected number of mice are found at E10.5 but fewer than expected are found at E12.5
|
|
• fetal livers contain very few erythrocytes but numbers of other hematopoietic lineage cells are similar to controls at E12.5
• severe impairment in the differentiation of proerythroblasts into erythroblasts in the fetal liver at E14.5
• total numbers of BFU-E and CFU-E are dramatically lower in fetal livers compared to controls
• however, embryonic erythropoiesis is similar to controls
|
|
• severe in embryos
• however, surviving adults have normal steady-state hematocrit
|
|
• dramatic reduction in the number of erythrocytes in the fetal liver at E14.5
|
|
• increase in the number of LSK cells in the fetal liver at E14.5
|
|
• cultured erythroid cells are more sensitive to apoptotic stimulation compared to control cells
|
|
• enlarged fetal liver cells and reduced total liver cellularity at E12.5 and E14.5
• livers contain very few hematopoietic cells unlike in controls at E12.5
|
|
• at E12.5
|
| N |
• despite recombination in endothelial cells, no obvious vascular defects are detected
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/07/2024 MGI 6.23 |
|
|
|
||
Analysis Tools