Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm2Gsc mutation
(1 available);
any
Nr3c1 mutation
(34 available)
Tg(Runx2-icre)1Jtuc mutation
(0 available)
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growth/size/body
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• males exhibit a slight increase in crown-rump length compared to controls at 10 weeks
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skeleton
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N |
• bone resorption is slightly decreased in both mutants and controls while osteoclast numbers are not affected
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• calvarial osteoblasts exhibit diminished differentiation potential in terms of bone nodule formation and alkaline phosphatase expression
• with prednisolone treatment, osteoblast differentiation is impaired in wild-type mice, but is unaffected in mutants, as determined by Col1a1 expression, marking functional osteoblasts
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• in response to two weeks of treatment with the Nr3c1 agonist prednisolone, mutants do not display reduced bone mineral density in vertebral bones in contrast to treated controls
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• mice show modest but highly significant decrease in bone density in calcified vertebral sections compared to controls at 3 months
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• trabecular numbers are decreased but trabecular thickness is unaltered resulting in increased trabecular spacing
• osteoblast numbers, osteoblast surface, osteocytes, and osteoclast parameters are not significantly changed compared to controls
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• bone formation in vertebrae is not inhibited whereas treated controls show near complete inhibition of bone formation with prednisolone treatment; osteoblastogenesis (numbers of colony forming units of osteoblasts) is not impaired as seen in controls with prednisolone treatment
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cellular
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• calvarial osteoblasts exhibit diminished differentiation potential in terms of bone nodule formation and alkaline phosphatase expression
• with prednisolone treatment, osteoblast differentiation is impaired in wild-type mice, but is unaffected in mutants, as determined by Col1a1 expression, marking functional osteoblasts
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2(Nfkbia)Rsu mutation
(0 available);
any
Ctnnb1 mutation
(49 available)
Tg(Runx2-icre)1Jtuc mutation
(0 available)
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skeleton
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N |
• osteoblast apoptosis is normal and differentiation is inhibited by dexamethasone treatment, similar to wild-type
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Tg(Runx2-icre)1Jtuc mutation
(0 available)
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skeleton
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• long bone osteoblasts exhibit an increased expression of inflammatory cytokines during osteoblast differentiation
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• osteoclast number is increased in lumbar vertebral bodies and tibiae and osteoclast-covered surface of lumbar vertebral bodies and tibiae is increased in males
• osteoclast surface per bone surface and osteoclast number per bone perimeter is increased in vertebral bodies of females
• however, no differences in osteoblast-covered surface or number are seen
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• femurs exhibit a smaller midshaft diameter
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• tibia show decreased midshaft diameter
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• decrease in trabecular bone volume in femurs and lumbar spine of males
• decrease in trabecular bone volume in lumbar spine of females
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• femurs show decreased cortical porosity
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• femurs and tibiae show an increase in cortical thickness
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• decrease in trabecula number in femurs and lumbar spine of males
• decrease in trabecula number in lumbar spine of females
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• increase in trabecular separation in femurs and lumbar spine
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• decrease in trabecular bone connection density
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• femurs show decreased trabecular mass
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• reduction in cortical mineralization of femurs
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• tibial endocortical bone surface shows an increase in endosteal mineralizing surface
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• tibial endocortical bone surface shows an increase in endosteal bone formation rate
• however, no differences in periosteal or trabecular bone formation parameters
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• the elastic modulus and work to reach ultimate stress levels are lower in femurs, indicating that femurs tolerate higher stress levels and are more elastic/flexible
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• two mice exhibit fracture with callus in the tibia
• femurs bear higher stress levels in the three-point bending tests but work-to-fracture is 42% lower
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cellular
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• long bone osteoblasts exhibit an increased expression of inflammatory cytokines during osteoblast differentiation
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hematopoietic system
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• osteoclast number is increased in lumbar vertebral bodies and tibiae and osteoclast-covered surface of lumbar vertebral bodies and tibiae is increased in males
• osteoclast surface per bone surface and osteoclast number per bone perimeter is increased in vertebral bodies of females
• however, no differences in osteoblast-covered surface or number are seen
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immune system
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• osteoclast number is increased in lumbar vertebral bodies and tibiae and osteoclast-covered surface of lumbar vertebral bodies and tibiae is increased in males
• osteoclast surface per bone surface and osteoclast number per bone perimeter is increased in vertebral bodies of females
• however, no differences in osteoblast-covered surface or number are seen
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limbs/digits/tail
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• femurs and tibiae show an increase in cortical thickness
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• femurs exhibit a smaller midshaft diameter
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• tibia show decreased midshaft diameter
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craniofacial
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N |
• mice exhibit normal calvarial bone thickness and porosity
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Analysis Tools