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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ltbrtm1Avt
targeted mutation 1, Alexei V Tumanov
MGI:4453317
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ltbrtm1Avt/Ltbrtm1Avt
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd MGI:4453320
cn2
 		Cd19tm1(cre)Cgn/Cd19+
Ltbrtm1Avt/Ltbrtm1Avt 		involves: 129P2/OlaHsd MGI:4453321
cn3
 		Cd19tm1(cre)Cgn/Cd19+
Ltbrtm1Avt/Ltbrtm1Avt
Tg(Lck-cre)I57Jxm/0 		involves: 129P2/OlaHsd MGI:4453323
cn4
 		Ltbrtm1Avt/Ltbrtm1Avt
Tg(Vil1-cre)997Gum/0 		involves: C57BL/6J * SJL MGI:4453319
cn5
 		Ltbrtm1Avt/Ltbrtm1Avt
Tg(Lck-cre)I57Jxm/0 		Not Specified MGI:4453322
cn6
 		Ltbrtm1Avt/Ltbrtm1Avt
Tg(Rorc-cre)1Litt/0 		Not Specified MGI:4453324


Genotype
MGI:4453320
cn1
Allelic
Composition		 Ltbrtm1Avt/Ltbrtm1Avt
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltbrtm1Avt mutation (0 available); any Ltbr mutation (47 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:158663 )
• display increased bacterial titers in the blood and feces
• despite this mice survive the infection




Genotype
MGI:4453321
cn2
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Ltbrtm1Avt/Ltbrtm1Avt
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Ltbrtm1Avt mutation (0 available); any Ltbr mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:158663 )
N
• susceptibility to Citrobacter rodentium infection is similar to wild-type controls




Genotype
MGI:4453323
cn3
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Ltbrtm1Avt/Ltbrtm1Avt
Tg(Lck-cre)I57Jxm/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Ltbrtm1Avt mutation (0 available); any Ltbr mutation (47 available)
Tg(Lck-cre)I57Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:158663 )
N
• susceptibility to Citrobacter rodentium infection is similar to wild-type controls




Genotype
MGI:4453319
cn4
Allelic
Composition		 Ltbrtm1Avt/Ltbrtm1Avt
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltbrtm1Avt mutation (0 available); any Ltbr mutation (47 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased neutrophil cell number ( J:158663 )
• neutrophil numbers are greatly reduced in the lamina propria
increased susceptibility to bacterial infection ( J:158663 )
• show a deficiency in clearing Citrobacter rodentium infection, and display 15-20 times higher bacterial titers in the spleen and feces compared to wild-type mice at days 10 and 14 after infection
• despite this most mice survive the infection

hematopoietic system
decreased neutrophil cell number ( J:158663 )
• neutrophil numbers are greatly reduced in the lamina propria




Genotype
MGI:4453322
cn5
Allelic
Composition		 Ltbrtm1Avt/Ltbrtm1Avt
Tg(Lck-cre)I57Jxm/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltbrtm1Avt mutation (0 available); any Ltbr mutation (47 available)
Tg(Lck-cre)I57Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:158663 )
N
• susceptibility to Citrobacter rodentium infection is similar to wild-type controls




Genotype
MGI:4453324
cn6
Allelic
Composition		 Ltbrtm1Avt/Ltbrtm1Avt
Tg(Rorc-cre)1Litt/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltbrtm1Avt mutation (0 available); any Ltbr mutation (47 available)
Tg(Rorc-cre)1Litt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:158663 )
• died at day 8-12 post-infection with C. rodentium

growth/size/body
weight loss ( J:158663 )
• exhibit weight loss post infection with C. rodentium

immune system
decreased neutrophil cell number ( J:158663 )
• reduced number of neutrophils in the colon lamina propria
abnormal chemokine level ( J:158663 )
• lower expression of CXCL1 and CXCL2 chemokines in the colon lamina propria
increased susceptibility to bacterial infection ( J:158663 )
• display weight loss, increased bacterial titers in the feces and blood and severe colon pathology after infection with Citrobacter rodentium
increased susceptibility to bacterial infection induced morbidity/mortality ( J:158663 )
• died at day 8-12 post-infection with C. rodentium

digestive/alimentary system
abnormal colon morphology ( J:158663 )
• display severe colon pathology post infection with C. rodentium

hematopoietic system
decreased neutrophil cell number ( J:158663 )
• reduced number of neutrophils in the colon lamina propria

homeostasis/metabolism
abnormal chemokine level ( J:158663 )
• lower expression of CXCL1 and CXCL2 chemokines in the colon lamina propria




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory