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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fzd7tm1.1Nat
targeted mutation 1.1 Jeremy Nathans
MGI:4442616
Summary 15 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fzd7tm1.1Nat/Fzd7tm1.1Nat involves: 129 * C57BL/6 MGI:4442831
cx2
 		Fzd1tm1.1Nat/Fzd1tm1.1Nat
Fzd7tm1.1Nat/Fzd7tm1.1Nat 		involves: 129 * C57BL/6 MGI:5444704
cx3
 		Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat 		involves: 129 * C57BL/6 MGI:5444706
cx4
 		Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt5atm1Amc/Wnt5a+ 		involves: 129 * C57BL/6 MGI:5444717
cx5
 		Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt5atm1Amc/Wnt5a+ 		involves: 129 * C57BL/6 MGI:5444718
cx6
 		Fzd2tm1.1Nat/Fzd2tm1.1Nat
Fzd7tm1.1Nat/Fzd7tm1.1Nat 		involves: 129 * C57BL/6 MGI:5444705
cx7
 		Dvl3tm1Awb/Dvl3+
Fzd7tm1.1Nat/Fzd7tm1.1Nat 		involves: 129 * C57BL/6 MGI:5444710
cx8
 		Dvl3tm1Awb/Dvl3+
Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat 		involves: 129 * C57BL/6 MGI:5444711
cx9
 		Dvl3tm1Awb/Dvl3tm1Awb
Fzd7tm1.1Nat/Fzd7tm1.1Nat 		involves: 129 * C57BL/6 MGI:5444712
cx10
 		Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt3atm1Amc/Wnt3a+ 		involves: 129 * C57BL/6 MGI:5444713
cx11
 		Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt3atm1Amc/Wnt3a+ 		involves: 129 * C57BL/6 MGI:5444714
cx12
 		Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt11tm1Amc/Wnt11+ 		involves: 129 * C57BL/6 MGI:5444716
cx13
 		Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Vangl2Lp/Vangl2+ 		involves: 129 * C57BL/6 * LPT/LeJ MGI:5444707
cx14
 		Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat 		involves: 129 * C57BL/6 * LPT/LeJ MGI:5444708
cx15
 		Fzd7tm1.1Nat/Fzd7tm1.1Nat
Vangl2Lp/Vangl2+ 		involves: 129 * C57BL/6 * LPT/LeJ MGI:5444709


Genotype
MGI:4442831
hm1
Allelic
Composition		 Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
short tail ( J:189062 )
• around 10% shorter than in controls
kinked tail ( J:189062 )
• distal kink

cardiovascular system
abnormal heart morphology ( J:189062 )
• 14% of embryos (n=14) display cardiac defects




Genotype
MGI:5444704
cx2
Allelic
Composition		 Fzd1tm1.1Nat/Fzd1tm1.1Nat
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd1tm1.1Nat mutation (1 available); any Fzd1 mutation (32 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
diluted coat color ( J:189062 )
• gray coat color

pigmentation
diluted coat color ( J:189062 )
• gray coat color




Genotype
MGI:5444706
cx3
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (32 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:189062 )
• more than 50% die postnatally
• survivors are viable and fertile

cardiovascular system
abnormal heart morphology ( J:189062 )
• 50% of embryos (n=22) display cardiac defects
double outlet right ventricle ( J:189062 )
• DORV in combination with a ventricular septal defect is occasionally seen

craniofacial
craniofacial phenotype ( J:189062 )
N
• Background Sensitivity: no palate closure defects are detected in mice on a mixed strain background including 129 and C57BL/6; however, palate closure defects are seen in mice on a mixed strain background including 129, C57BL/6 and LPT/LeJ




Genotype
MGI:5444717
cx4
Allelic
Composition		 Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt5atm1Amc/Wnt5a+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
Wnt5atm1Amc mutation (1 available); any Wnt5a mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
short tail ( J:189062 )
• truncation is more severe than in mice homozygous for Fzd7tm1.1Nat alone




Genotype
MGI:5444718
cx5
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt5atm1Amc/Wnt5a+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (32 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
Wnt5atm1Amc mutation (1 available); any Wnt5a mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
embryonic growth retardation ( J:189062 )
• starting at E9.5

embryo
embryonic growth retardation ( J:189062 )
• starting at E9.5




Genotype
MGI:5444705
cx6
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2tm1.1Nat
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (32 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
disorganized yolk sac vascular plexus ( J:189062 )
• fail to develop an organized vascular plexus at E9.5
incomplete embryo turning ( J:189062 )
• fail to complete tail turning
decreased embryo size ( J:189062 )
• modest decrease in size at E8.5
abnormal embryonic tissue morphology ( J:189062 )
• strikingly rotund morphology at E8.5 (length:width ratio of around 2 compared to around 3.5 in controls)
abnormal parietal yolk sac morphology ( J:189062 )
• at E10.5 the yolk sac vasculature is engorged with blood

cardiovascular system
decreased angiogenesis ( J:189062 )
• rudimentary vasculature at E9.5
disorganized yolk sac vascular plexus ( J:189062 )
• fail to develop an organized vascular plexus at E9.5
abnormal heart development ( J:189062 )
• fail to develop left-right heart asymmetry

nervous system

growth/size/body
embryonic growth retardation ( J:189062 )
• at E8.5
decreased embryo size ( J:189062 )
• modest decrease in size at E8.5




Genotype
MGI:5444710
cx7
Allelic
Composition		 Dvl3tm1Awb/Dvl3+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (37 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 50% of embryos (n=14) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs




Genotype
MGI:5444711
cx8
Allelic
Composition		 Dvl3tm1Awb/Dvl3+
Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (37 available)
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (32 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 83% of embryos (n=12) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs




Genotype
MGI:5444712
cx9
Allelic
Composition		 Dvl3tm1Awb/Dvl3tm1Awb
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (37 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• all (3 of 3) embryos display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs




Genotype
MGI:5444713
cx10
Allelic
Composition		 Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt3atm1Amc/Wnt3a+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
Wnt3atm1Amc mutation (1 available); any Wnt3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 37% of embryos (n=16) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs




Genotype
MGI:5444714
cx11
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt3atm1Amc/Wnt3a+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (32 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
Wnt3atm1Amc mutation (1 available); any Wnt3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 92% of embryos (n=12) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs

craniofacial
cleft palate ( J:189062 )
• in 14% of embryos (n=14)

digestive/alimentary system
cleft palate ( J:189062 )
• in 14% of embryos (n=14)

growth/size/body
cleft palate ( J:189062 )
• in 14% of embryos (n=14)




Genotype
MGI:5444716
cx12
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt11tm1Amc/Wnt11+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (32 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
Wnt11tm1Amc mutation (3 available); any Wnt11 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 100% of embryos (n=10) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs

craniofacial
cleft palate ( J:189062 )
• in 11% of embryos (n=9)

digestive/alimentary system
cleft palate ( J:189062 )
• in 11% of embryos (n=9)

growth/size/body
cleft palate ( J:189062 )
• in 11% of embryos (n=9)




Genotype
MGI:5444707
cx13
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129 * C57BL/6 * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (32 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 37% of embryos (n=18) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs

craniofacial
cleft palate ( J:189062 )
• in 53% of embryos (n=17)

digestive/alimentary system
cleft palate ( J:189062 )
• in 53% of embryos (n=17)

growth/size/body
cleft palate ( J:189062 )
• in 53% of embryos (n=17)




Genotype
MGI:5444708
cx14
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Genetic
Background		 involves: 129 * C57BL/6 * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (32 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:189062 )
• Background Sensitivity: seen in 15% of embryos (n=13) in mice on a mixed strain background containing 129, C57BL/6 and LPT/LeJ; however, cleft palate is not seen in mice on mixed strain background including 129 and C57BL/6 but not LPT/LeJ

digestive/alimentary system
cleft palate ( J:189062 )
• Background Sensitivity: seen in 15% of embryos (n=13) in mice on a mixed strain background containing 129, C57BL/6 and LPT/LeJ; however, cleft palate is not seen in mice on mixed strain background including 129 and C57BL/6 but not LPT/LeJ

growth/size/body
cleft palate ( J:189062 )
• Background Sensitivity: seen in 15% of embryos (n=13) in mice on a mixed strain background containing 129, C57BL/6 and LPT/LeJ; however, cleft palate is not seen in mice on mixed strain background including 129 and C57BL/6 but not LPT/LeJ




Genotype
MGI:5444709
cx15
Allelic
Composition		 Fzd7tm1.1Nat/Fzd7tm1.1Nat
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129 * C57BL/6 * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 35% of embryos (n=20) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs

craniofacial
cleft palate ( J:189062 )
• in 4% of embryos (n=25)

digestive/alimentary system
cleft palate ( J:189062 )
• in 4% of embryos (n=25)

growth/size/body
cleft palate ( J:189062 )
• in 4% of embryos (n=25)




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory