Phenotypes associated with this allele

• Allele Symbol: Edn2^tm1.1Nat
• Allele Name: targeted mutation 1.1, Jeremy Nathans
• Allele ID: MGI:4438396
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Edn2^tm1.1Nat/Edn2^tm1.1Nat Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:4438398
cn2	Edn2^tm1.1Nat/Edn2^tm1.1Nat Tg(Vil1-cre)997Gum/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL	MGI:5519892
cn3	Edn2^tm1.1Nat/Edn2^tm1.1Nat Tg(Nes-cre)1Kln/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5519893

Genotype
MGI:4438398

cn1

• Allelic Composition: Edn2^tm1.1Nat/Edn2^tm1.1Nat; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Impaired lung morphology in Edn2^tm1Ywa/Edn2^tm1Ywa mice and tamoxifen-treated Edn2^tm1.1Nat/Edn2^tm1.1Nat Tg(CAG-cre/Esr1*)5Amc/0 mice

mortality/aging

premature death ( J:201436 )

• in mice treated with tamoxifen at P0

• however, adult mice treated with tamoxifen exhibit normal survival

postnatal lethality, incomplete penetrance ( J:201436 )

• in mice treated with tamoxifen at P0

homeostasis/metabolism

impaired adaptive thermogenesis ( J:201436 )

• decreased body temperature in response to cold exposure in mice treated with tamoxifen

acidemia ( J:201436 )

• blood pH is more acidic in tamoxifen-treated mice

increased circulating bicarbonate level ( J:201436 )

• in tamoxifen-treated mice

decreased circulating glucose level ( J:201436 )

• in mice treated with tamoxifen at P0 or 6 weeks of age

decreased body temperature ( J:201436 )

• in mice treated with tamoxifen at P0 or 6 weeks of age

hypercapnia ( J:201436 )

• in tamoxifen-treated mice

acidosis ( J:201436 )

• blood pH is more acidic in tamoxifen-treated mice

growth/size/body

decreased body weight ( J:201436 )

• in mice treated with tamoxifen at P0 or 6 weeks of age

postnatal growth retardation ( J:201436 )

• in mice treated with tamoxifen at P0 or 6 weeks of age

respiratory system

abnormal pulmonary alveolar sac morphology ( J:201436 )

• tamoxifen-treated mice exhibit enlarged air spaces with simplification of the alveolar structure

abnormal pulmonary alveolus morphology ( J:201436 )

• simplified structure in tamoxifen-treated mice

adipose tissue

decreased total body fat amount ( J:201436 )

• after 10 weeks of tamoxifen-induced activation

Genotype
MGI:5519892

cn2

• Allelic Composition: Edn2^tm1.1Nat/Edn2^tm1.1Nat; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

mortality/aging

mortality/aging ( J:201436 )

N • mice exhibit normal survival

digestive/alimentary system

digestive/alimentary phenotype ( J:201436 )

N • mice exhibit normal fat and carbohydrate absorption and excretion

growth/size/body

growth/size/body region phenotype ( J:201436 )

N • mice exhibit normal growth

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:201436 )

N • mice exhibit normal blood glucose levels and body temperature regulation

Genotype
MGI:5519893

cn3

• Allelic Composition: Edn2^tm1.1Nat/Edn2^tm1.1Nat; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

growth/size/body

growth/size/body region phenotype ( J:201436 )

N • mice exhibit normal growth

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:201436 )

N • mice exhibit normal core body temperature, even in a cold environment