All Phenotypes Adamts9<tm1Dgen> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adamts9^tm1Dgen
targeted mutation 1, Deltagen
MGI:4418751

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamts9^tm1Dgen/Adamts9^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:4418867
ht2	Adamts9^tm1Dgen/Adamts9^tm1.2Apte	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL	MGI:5603308
cx3	Adamts5^tm1Dgen/Adamts5^tm1Dgen Adamts9^tm1Dgen/Adamts9⁺	B6.129P2-Adamts9^tm1Dgen Adamts5^tm1Dgen	MGI:4418860
cx4	Adamts9^tm1Dgen/Adamts9^tm1Dgen Fbln1^{Gt(XST011)Byg}/Fbln1⁺	B6.129P2-Adamts9^tm1Dgen Fbln1^{Gt(XST011)Byg}	MGI:4418863
cx5	Adamts20^bt-Bei1/Adamts20^bt-Bei1 Adamts9^tm1Dgen/Adamts9⁺	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1	MGI:4418877
cx6	Adamts20^bt-Bei1/Adamts20⁺ Adamts5^tm1Dgen/Adamts5⁺ Adamts9^tm1Dgen/Adamts9⁺	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1 Adamts5^tm1Dgen	MGI:4418865
cx7	Adamts20^bt-Bei1/Adamts20⁺ Adamts5^tm1Dgen/Adamts5^tm1Dgen Adamts9^tm1Dgen/Adamts9⁺	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1 Adamts5^tm1Dgen	MGI:4418861
cx8	Adamts9^tm1Dgen/Adamts9^tm1Dgen Vcan^{Tg(Hoxa1)1Chm}/Vcan⁺	B6.Cg-Adamts9^tm1Dgen Vcan^{Tg(Hoxa1)1Chm}	MGI:4418862
cx9	Adamts20^bt-2H/Adamts20^bt-2H Adamts9^tm1Dgen/Adamts9⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4418869

Allelic Composition	Adamts9^tm1Dgen/Adamts9^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^tm1Dgen mutation (0 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:133403 , J:155754 )

• lethal prior to gastrulation (J:133403)

• mutant embryos die during early gestation (J:155754)

Allelic Composition	Adamts9^tm1Dgen/Adamts9^tm1.2Apte
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^tm1.2Apte mutation (1 available); any Adamts9 mutation (90 available)
Adamts9^tm1Dgen mutation (0 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:213412 )

• no viable embryos are identified at E9.5

Allelic Composition	Adamts5^tm1Dgen/Adamts5^tm1Dgen Adamts9^tm1Dgen/Adamts9⁺
Genetic Background	B6.129P2-Adamts9^tm1Dgen Adamts5^tm1Dgen

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5^tm1Dgen mutation (1 available); any Adamts5 mutation (54 available)
Adamts9^tm1Dgen mutation (0 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:155754 )

• 87% penetrance of soft-tissue syndactyly (STS)

interdigital webbing ( J:155754 )

Allelic Composition	Adamts9^tm1Dgen/Adamts9^tm1Dgen Fbln1^{Gt(XST011)Byg}/Fbln1⁺
Genetic Background	B6.129P2-Adamts9^tm1Dgen Fbln1^{Gt(XST011)Byg}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^tm1Dgen mutation (0 available); any Adamts9 mutation (90 available)
Fbln1^{Gt(XST011)Byg} mutation (0 available); any Fbln1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:155754 )

• 100% penetrance of soft-tissue syndactyly (STS)

interdigital webbing ( J:155754 )

Allelic Composition	Adamts20^bt-Bei1/Adamts20^bt-Bei1 Adamts9^tm1Dgen/Adamts9⁺
Genetic Background	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20^bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)
Adamts9^tm1Dgen mutation (0 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:155754 )

• 100% penetrance of soft-tissue syndactyly (STS, n=5)

interdigital webbing ( J:155754 )

Allelic Composition	Adamts20^bt-Bei1/Adamts20⁺ Adamts5^tm1Dgen/Adamts5⁺ Adamts9^tm1Dgen/Adamts9⁺
Genetic Background	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1 Adamts5^tm1Dgen

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20^bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)
Adamts5^tm1Dgen mutation (1 available); any Adamts5 mutation (54 available)
Adamts9^tm1Dgen mutation (0 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:155754 )

• partial penetrance of soft-tissue syndactyly (STS)

interdigital webbing ( J:155754 )

Allelic Composition	Adamts20^bt-Bei1/Adamts20⁺ Adamts5^tm1Dgen/Adamts5^tm1Dgen Adamts9^tm1Dgen/Adamts9⁺
Genetic Background	B6.Cg-Adamts9^tm1Dgen Adamts20^bt-Bei1 Adamts5^tm1Dgen

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:155754 )

• fully penetrant soft-tissue syndactyly (STS)

• more affected limbs than littermate control

interdigital webbing ( J:155754 )

Allelic Composition	Adamts9^tm1Dgen/Adamts9^tm1Dgen Vcan^{Tg(Hoxa1)1Chm}/Vcan⁺
Genetic Background	B6.Cg-Adamts9^tm1Dgen Vcan^{Tg(Hoxa1)1Chm}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^tm1Dgen mutation (0 available); any Adamts9 mutation (90 available)
Vcan^{Tg(Hoxa1)1Chm} mutation (0 available); any Vcan mutation (164 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:155754 )

• 100% penetrance of soft-tissue syndactyly (STS)

interdigital webbing ( J:155754 )

Allelic Composition	Adamts20^bt-2H/Adamts20^bt-2H Adamts9^tm1Dgen/Adamts9⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20^bt-2H mutation (2 available); any Adamts20 mutation (93 available)
Adamts9^tm1Dgen mutation (0 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:133403 )

• die shortly after birth

pigmentation

abnormal coat/hair pigmentation ( J:133403 )

• de-pigmentation is apparent on 75% of the anterior-posterior length (n=5) in the trunk skin samples from newborn mutants

embryo

abnormal melanoblast morphology ( J:133403 )

• significant reduction in melanoblasts in the trunk and head region of E13.5 embryos

nervous system

abnormal melanoblast morphology ( J:133403 )

• significant reduction in melanoblasts in the trunk and head region of E13.5 embryos

integument

abnormal coat/hair pigmentation ( J:133403 )

• de-pigmentation is apparent on 75% of the anterior-posterior length (n=5) in the trunk skin samples from newborn mutants

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