All Phenotypes Cebpb<tm1Nerl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cebpb^tm1Nerl
targeted mutation 1, Claus Nerlov
MGI:4366801

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cebpa^tm1Gonz/Cebpa⁺ Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	MGI:4366854
cn2	Cebpa^tm1Gonz/Cebpa^tm2Nerl Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	MGI:4366855
cn3	Cebpa^tm1Gonz/Cebpa^tm9Nerl Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	MGI:4366856
cn4	Cebpa^tm1Gonz/Cebpa^tm1Gonz Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	MGI:4366857
cn5	Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(Ckmm-cre)5Khn/0	involves: 129P2/OlaHsd * C57BL/6 * FVB	MGI:4366867

Allelic Composition	Cebpa^tm1Gonz/Cebpa⁺ Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpa^tm1Gonz mutation (1 available); any Cebpa mutation (16 available)
Cebpb^tm1Nerl mutation (0 available); any Cebpb mutation (23 available)
Tg(KRT14-cre)1Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:154022 )

N	• mice have normal epidermis

Allelic Composition	Cebpa^tm1Gonz/Cebpa^tm2Nerl Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpa^tm1Gonz mutation (1 available); any Cebpa mutation (16 available)
Cebpa^tm2Nerl mutation (0 available); any Cebpa mutation (16 available)
Cebpb^tm1Nerl mutation (0 available); any Cebpb mutation (23 available)
Tg(KRT14-cre)1Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

increased keratinocyte proliferation ( J:154022 )

abnormal epidermis stratum corneum morphology ( J:154022 )

• intermediate phenotype

abnormal epidermis stratum granulosum morphology ( J:154022 )

• intermediate phenotype

shiny skin ( J:154022 )

cellular

increased keratinocyte proliferation ( J:154022 )

Allelic Composition	Cebpa^tm1Gonz/Cebpa^tm9Nerl Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpa^tm1Gonz mutation (1 available); any Cebpa mutation (16 available)
Cebpa^tm9Nerl mutation (0 available); any Cebpa mutation (16 available)
Cebpb^tm1Nerl mutation (0 available); any Cebpb mutation (23 available)
Tg(KRT14-cre)1Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

increased keratinocyte proliferation ( J:154022 )

absent epidermis stratum corneum ( J:154022 )

parakeratosis ( J:154022 )

absent epidermis stratum granulosum ( J:154022 )

shiny skin ( J:154022 )

cellular

increased keratinocyte proliferation ( J:154022 )

Allelic Composition	Cebpa^tm1Gonz/Cebpa^tm1Gonz Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:154022 )

• mice die within 5 to 8 hours of birth

growth/size/body

weight loss ( J:154022 )

• at birth mice loss weight rapidly likely due to severe transepithelial water loss without lipophilic barrier dysfunction

vision/eye

eyelids open at birth ( J:154022 )

integument

increased keratinocyte proliferation ( J:154022 )

• at E18.5

abnormal epidermal layer morphology ( J:154022 )

• the interfollicular epidermis exhibits an immature phenotype with fewer and smaller keratohyalin granules in the stratum granulosum and immature non-scaling stratum corneum and parakeratosis compared with wild-type mice

parakeratosis ( J:154022 )

shiny skin ( J:154022 )

tight skin ( J:154022 )

cellular

increased keratinocyte proliferation ( J:154022 )

• at E18.5

Allelic Composition	Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(Ckmm-cre)5Khn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpb^tm1Nerl mutation (0 available); any Cebpb mutation (23 available)
Tg(Ckmm-cre)5Khn mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:153686 )

N	• mice exhibit normal muscle regeneration in response to treatment with cardiotoxin

muscle

muscle phenotype ( J:153686 )

N	• mice exhibit normal muscle regeneration in response to treatment with cardiotoxin

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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