Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm1Pwt mutation
(0 available);
any
Bcl11a mutation
(42 available)
Kdm1atm1.1Sho mutation
(1 available);
any
Kdm1a mutation
(39 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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hematopoietic system
immune system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm1Pwt mutation
(0 available);
any
Bcl11a mutation
(42 available)
Dnmt1tm2Jae mutation
(1 available);
any
Dnmt1 mutation
(108 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm1Pwt mutation
(0 available);
any
Bcl11a mutation
(42 available)
Gt(ROSA)26Sortm1(EYFP)Cos mutation
(11 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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cellular
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• following pIpC induction cultured precursor cells fail to produce plasmacytoid dendritic cells
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hematopoietic system
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• following pIpC induction cultured precursor cells fail to produce plasmacytoid dendritic cells
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• mild decrease in the total number of cells in GM-CSF-supplemented cultures following pIpC treatment
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• following pIpC induction cultured precursor cells fail to produce plasmacytoid dendritic cells and in vivo
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• in Flt3L-supplemented cultures following pIpC induced deletion in hematopoietic stem cells and in vivo
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immune system
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• following pIpC induction cultured precursor cells fail to produce plasmacytoid dendritic cells
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• mild decrease in the total number of cells in GM-CSF-supplemented cultures following pIpC treatment
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• following pIpC induction cultured precursor cells fail to produce plasmacytoid dendritic cells and in vivo
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• in Flt3L-supplemented cultures following pIpC induced deletion in hematopoietic stem cells and in vivo
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm1Pwt mutation
(0 available);
any
Bcl11a mutation
(42 available)
Eportm1.1(EGFP/icre)Uk mutation
(2 available);
any
Epor mutation
(25 available)
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hematopoietic system
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N |
• mice exhibit normal red blood cell numbers, white blood cell numbers and hemoglobin content
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm1Pwt mutation
(0 available);
any
Bcl11a mutation
(42 available)
Commd10Tg(Vav1-icre)A2Kio mutation
(3 available);
any
Commd10 mutation
(24 available)
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hematopoietic system
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N |
• granulocytes, T cells, macrophage conventional dendritic cells and dendritic cell progenitors not affected in spleen and bone marrow
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• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• also reduced in the spleen but not as severely as in the bone marrow
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• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• proportionate to the loss of plasmacytoid dendritic cell in bone marrow and spleen
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• about a 2-fold decrease in the bone marrow
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immune system
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• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• also reduced in the spleen but not as severely as in the bone marrow
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• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• proportionate to the loss of plasmacytoid dendritic cell in bone marrow and spleen
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• following infection with human HSV strain 17
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm1Pwt mutation
(0 available);
any
Bcl11a mutation
(42 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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hematopoietic system
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N |
• mice exhibit normal red blood cell numbers and hemoglobin content
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immune system
Analysis Tools
