Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif7maki mutation
(0 available);
any
Kif7 mutation
(39 available)
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Diaphragmatic hernia in Kif7maki/Kif7maki mice
muscle
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• central tendon patterning defects at E17.5
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• left-sided communicating diaphragmatic hernias
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skeleton
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• central tendon patterning defects at E17.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3Xt mutation
(1 available);
any
Gli3 mutation
(80 available)
Kif7maki mutation
(0 available);
any
Kif7 mutation
(39 available)
Tg(Hlxb9-GFP)1Tmj mutation
(3 available)
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nervous system
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• expansion of the ventral neural cell types is increased compared to Kif7 single mutants
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embryo
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• expansion of the ventral neural cell types is increased compared to Kif7 single mutants
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2tm1Alj mutation
(0 available);
any
Gli2 mutation
(169 available)
Kif7maki mutation
(0 available);
any
Kif7 mutation
(39 available)
Tg(Hlxb9-GFP)1Tmj mutation
(3 available)
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nervous system
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• unlike in Kif7 single mutants, in compound mutants the motor neuron domain is not expanded dorsally and the Nkx2.2+ domain is absent
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embryo
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• unlike in Kif7 single mutants, in compound mutants the motor neuron domain is not expanded dorsally and the Nkx2.2+ domain is absent
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif7maki mutation
(0 available);
any
Kif7 mutation
(39 available)
Ptch1tm1Mps mutation
(2 available);
any
Ptch1 mutation
(115 available)
Tg(Hlxb9-GFP)1Tmj mutation
(3 available)
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mortality/aging
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• compound mutants develop until E10.5, unlike Ptch1 single mutants that arrest at about E9.0
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nervous system
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• ventral cell types are expanded to encompass about 3/4 of the neural plate
• this expansion is less than that seen in Ptch1 single mutants
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embryo
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• ventral cell types are expanded to encompass about 3/4 of the neural plate
• this expansion is less than that seen in Ptch1 single mutants
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif7maki mutation
(0 available);
any
Kif7 mutation
(39 available)
Tg(Hlxb9-GFP)1Tmj mutation
(3 available)
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mortality/aging
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• die at the end of gestation
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nervous system
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• at E10.5 the motor neuron region is expanded dorsally
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• at E10.5 the motor neuron region is expanded dorsally in the neural tube
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• at E10.5 in the neural tube
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limbs/digits/tail
embryo
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• at E10.5 the motor neuron region is expanded dorsally
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif7maki mutation
(0 available);
any
Kif7 mutation
(39 available)
Smobnb mutation
(0 available);
any
Smo mutation
(39 available)
Tg(Hlxb9-GFP)1Tmj mutation
(3 available)
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mortality/aging
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• compound mutants develop until E10.5, unlike Smo single mutants that die at or before E9.0
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nervous system
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• unlike Smo single mutants, compound mutants develop ventral neural types
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift172wim mutation
(0 available);
any
Ift172 mutation
(75 available)
Kif7maki mutation
(0 available);
any
Kif7 mutation
(39 available)
Tg(Hlxb9-GFP)1Tmj mutation
(3 available)
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nervous system
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• phenotype is indistinguishable for that of Ift172 single mutants with the absence of Nkx2.2+ cells and few motor neurons in the neural tube
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embryo
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• phenotype is indistinguishable for that of Ift172 single mutants with the absence of Nkx2.2+ cells and few motor neurons in the neural tube
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dync2h1mmi mutation
(0 available);
any
Dync2h1 mutation
(215 available)
Kif7maki mutation
(0 available);
any
Kif7 mutation
(39 available)
Tg(Hlxb9-GFP)1Tmj mutation
(3 available)
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nervous system
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• lack ventral neural cell types
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• have only a very small number of motor neurons at all rostrocaudal positions in the spinal cord
• loss of motor neurons is increased compared to Dync2h1 single mutants
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embryo
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• lack ventral neural cell types
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