|
Allele Symbol Allele Name Allele ID |
Etv6tm1(RUNX1)Haho targeted mutation 1, Hanno Hock MGI:4355899 |
||||||||||||||||||||||||||||||||
| Summary |
7 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• all mice die within 8 days of treatment with pIpC unlike control mice
|
|
• following pIpC treatment
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• following treatment with pIpC, the number of progenitors, enriched hematopoietic stem cells, and pure hematopoietic stem cells are increased compared to similarly treated wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mildly
|
|
• transplantation of fetal liver cells into Rag null mice exhibit a decrease in early B cells confirms a specific adult block in B cell development
|
|
• myeloid progenitors are increased compared to in untreated mice
|
|
• early be cells is almost completely depleted
|
|
• mildly
|
|
• mildly
|
|
• transplantation of fetal liver cells into Rag null mice exhibit a decrease in early B cells confirms a specific adult block in B cell development
|
|
• early be cells is almost completely depleted
|
|
• mildly
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• following induction with pIpC, CFU-GMs (colony forming units Granulocyte-Macrophage, myeloid) are increased and CFU-IL-7 (early B-lineage committed, lymphoid) are decreased compared to in control mice
|
|
• following induction with pIpC, CFU-GEMMs (colony forming units Granulocyte, Erythroid, Macrophage, Megakaryocyte) are increased compared to in control mice
|
|
• in repopulation assays, bone marrow cells from pIpC treated lead to reduced donor-derived lymphocyte numbers compared to when untreated cells are used
|
|
• following pIpC treatment, myeloid progenitors are increased compared to in untreated mice
|
|
• following pIpC treatment, common lymphoid progenitors and lymphoid-primed multipotential progenitor are decreased compared to in untreated mice
|
|
• following induction with pIpC, BFU-Es (Burst-forming erythroid; early erythroid-committed, myeloid) are decreased compared to in controls
|
|
• mild to moderate following pIpC treatment
|
|
• mild to moderate following pIpC treatment
|
|
• mild to moderate following pIpC treatment
|
|
• B cells are gradually lost following pIpC treatment
|
|
• following pIpC treatment, the long term repopulating hematopoietic stem cells are increased 10-fold compared to in untreated mice
• in repopulation assays, bone marrow cells from pIpC treated lead to a 10-fold increase in long term repopulation hematopoietic stem cells compared to when untreated cells are used
• following pIpC treatment, the total number of cycling hematopoietic stem cells compared to in untreated mice
|
|
• the proportion of quiescent (G0) hematopoietic stem cells in the bone marrow of pIpC-treated mice is increased 17-fold compared with untreated controls
• following serum and cytokine withdrawal, the hematopoietic stem cells in the bone marrow of pIpC-treated mice exhibit increased apoptosis compared with untreated controls
• following induction with pIpC, hematopoietic stem cells used in serial transplantation experiments exhaust earlier than wild-type cells
|
|
• following induction with pIpC and treatment with ENU, latency is shortened and a higher proportion of mice develop malignacy compared to control mice
|
|
• following induction with pIpC and treatment with ENU, mice develop aggressive T cell leukemias with high blast counts and replacement of normal bone marrow with CD4+ CD8+ lymphoblasts unlike in control mice
|
|
• following induction with pIpC and treatment with ENU, latency is shortened and a higher proportion of mice develop malignacy compared to control mice
|
| N |
• T cell development is normal following pIpC induction
|
|
• in repopulation assays, bone marrow cells from pIpC treated lead to reduced donor-derived lymphocyte numbers compared to when untreated cells are used
|
|
• following pIpC treatment, myeloid progenitors are increased compared to in untreated mice
|
|
• mild to moderate following pIpC treatment
|
|
• mild to moderate following pIpC treatment
|
|
• B cells are gradually lost following pIpC treatment
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice die postnatally due to severe submucosal lymphedema of the small intestine
|
|
• in 30% of mice die before E10.5
|
| N |
• B cell development is normal with normal numbers of mature B cells
|
|
• the number of IL7 colony progenitors that form from E14.5 fetal liver cells is increased compared to when wild-type fetal liver cells are similarly treated
• serial replating of E14.5 fetal liver cells with IL7, SCF (stem cell factor), and Flt3L (Flt3 ligand) leads to an increase in colony numbers compared to when wild-type fetal liver cells are similarly treated
• however, fetal liver cell generated colonies are factor-dependent and not transformed
• bone marrow transplanted into irradiated Rag null mice fail to reconstitute the lymphocyte, pro-B cell, pre-B cells and IgM+ B cell compartments unlike when wild-type cells are transplanted
|
|
• mice die postnatally due to severe submucosal lymphedema of the small intestine
|
|
• mice fail to thrive
|
|
• mice die postnatally due to severe submucosal lymphedema of the small intestine
|
| N |
• unlike in other mice lacking Etv6 expression, yolk vascular development is normal in mice that survive beyond E10.5
|
|
• the number of IL7 colony progenitors that form from E14.5 fetal liver cells is increased compared to when wild-type fetal liver cells are similarly treated
• serial replating of E14.5 fetal liver cells with IL7, SCF (stem cell factor), and Flt3L (Flt3 ligand) leads to an increase in colony numbers compared to when wild-type fetal liver cells are similarly treated
• however, fetal liver cell generated colonies are factor-dependent and not transformed
• bone marrow transplanted into irradiated Rag null mice fail to reconstitute the lymphocyte, pro-B cell, pre-B cells and IgM+ B cell compartments unlike when wild-type cells are transplanted
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||
Analysis Tools