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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ifnb1tm2.1Lien
targeted mutation 2.1, Stefan Lienenklaus
MGI:4355683
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ifnb1tm2.1Lien/Ifnb1tm2.1Lien
Tyrc-2J/Tyrc-2J
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:5007898
cn2
 		Ifnb1tm2.1Lien/Ifnb1tm2.1Lien
Tg(Itgax-cre)1-1Reiz/0
Tyrc-2J/Tyrc-2J 		involves: C57BL/6 * CBA MGI:5007897
cx3
 		Ifnb1tm2.1Lien/Ifnb1tm2.1Lien
Tyrc-2J/Tyrc-2J 		involves: C57BL/6 MGI:5007896


Genotype
MGI:5007898
cn1
Allelic
Composition		 Ifnb1tm2.1Lien/Ifnb1tm2.1Lien
Tyrc-2J/Tyrc-2J
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnb1tm2.1Lien mutation (0 available); any Ifnb1 mutation (20 available)
Lyz2tm1(cre)Ifo mutation (16 available); any Lyz2 mutation (40 available)
Tyrc-2J mutation (28 available); any Tyr mutation (382 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased circulating interferon-alpha level ( J:172226 )
• following L. monocytogenes infection
decreased circulating interferon-beta level ( J:172226 )
• following L. monocytogenes infection
decreased susceptibility to bacterial infection ( J:172226 )
• following L. monocytogenes infection, mice exhibit decreased circulating interferon-alpha and -beta and decreased bacterial numbers in the spleen and liver compared with wild-type mice

homeostasis/metabolism
decreased circulating interferon-alpha level ( J:172226 )
• following L. monocytogenes infection
decreased circulating interferon-beta level ( J:172226 )
• following L. monocytogenes infection




Genotype
MGI:5007897
cn2
Allelic
Composition		 Ifnb1tm2.1Lien/Ifnb1tm2.1Lien
Tg(Itgax-cre)1-1Reiz/0
Tyrc-2J/Tyrc-2J
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnb1tm2.1Lien mutation (0 available); any Ifnb1 mutation (20 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
Tyrc-2J mutation (28 available); any Tyr mutation (382 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:172226 )
N
• mice exhibit normal response to L. monocytogenes infection




Genotype
MGI:5007896
cx3
Allelic
Composition		 Ifnb1tm2.1Lien/Ifnb1tm2.1Lien
Tyrc-2J/Tyrc-2J
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnb1tm2.1Lien mutation (0 available); any Ifnb1 mutation (20 available)
Tyrc-2J mutation (28 available); any Tyr mutation (382 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:172226 )
N
• mice exhibit normal response to L. monocytogenes infection




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory