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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hdac2tm1.1Rdp
targeted mutation 1.1, Ronald DePinho
MGI:3844983
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hdac1tm1.1Mrl/Hdac1tm1.1Mrl
Hdac2tm1.1Rdp/Hdac2tm1.1Rdp
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5494632
cn2
 		Hdac1tm1.1Mrl/Hdac1tm1.1Mrl
Hdac2tm1.1Rdp/Hdac2+
Tg(Mx1-cre)1Cgn/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:5494631
cn3
 		Hdac1tm1.1Mrl/Hdac1tm1.1Mrl
Hdac2tm1.1Rdp/Hdac2tm1.1Rdp
Tg(Mx1-cre)1Cgn/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:5494633


Genotype
MGI:5494632
cn1
Allelic
Composition		 Hdac1tm1.1Mrl/Hdac1tm1.1Mrl
Hdac2tm1.1Rdp/Hdac2tm1.1Rdp
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Hdac1tm1.1Mrl mutation (0 available); any Hdac1 mutation (36 available)
Hdac2tm1.1Rdp mutation (1 available); any Hdac2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitosis ( J:197818 )
• tamoxifen-treated mouse embryonic fibroblasts exhibit a 2-fold reduction in S-phase cells and an increase in G1 phase cell compared with control cells
decreased fibroblast proliferation ( J:197818 )
• tamoxifen-treated mouse embryonic fibroblasts exhibit growth arrest compared with control cells
early cellular replicative senescence ( J:197818 )
• in tamoxifen-treated mouse embryonic fibroblasts




Genotype
MGI:5494631
cn2
Allelic
Composition		 Hdac1tm1.1Mrl/Hdac1tm1.1Mrl
Hdac2tm1.1Rdp/Hdac2+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1tm1.1Mrl mutation (0 available); any Hdac1 mutation (36 available)
Hdac2tm1.1Rdp mutation (1 available); any Hdac2 mutation (38 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
anemia ( J:197818 )
• in pIpC-treated mice
decreased bone marrow cell number ( J:197818 )
• in pIpC-treated mice
abnormal megakaryocyte morphology ( J:197818 )
• megakaryocytes from pIpC-treated mice exhibit aberrant nuclear morphology and mitotic figures and are frequently found intra-vascular or extravasating into bone marrow blood vessels and in the liver compared with control cells
decreased megakaryocyte cell number ( J:197818 )
• in the bone marrow of pIpC-treated mice without increased apoptosis
decreased erythrocyte cell number ( J:197818 )
• 2-fold in pIpC-treated mice
thrombocytopenia ( J:197818 )
• 6-fold in pIpC-treated mice

behavior/neurological
lethargy ( J:197818 )
• in pIpC-treated mice




Genotype
MGI:5494633
cn3
Allelic
Composition		 Hdac1tm1.1Mrl/Hdac1tm1.1Mrl
Hdac2tm1.1Rdp/Hdac2tm1.1Rdp
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1tm1.1Mrl mutation (0 available); any Hdac1 mutation (36 available)
Hdac2tm1.1Rdp mutation (1 available); any Hdac2 mutation (38 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:197818 )
• mice are moribund 9 days after pIpC treatment

hematopoietic system
anemia ( J:197818 )
• in pIpC-treated mice
decreased bone marrow cell number ( J:197818 )
• in pIpC-treated mice
decreased megakaryocyte cell number ( J:197818 )
• 20-fold in the bone marrow of pIpC-treated mice with increased apoptosis
decreased erythrocyte cell number ( J:197818 )
• 5-fold in pIpC-treated mice
thrombocytopenia ( J:197818 )
• 16-fold in pIpC-treated mice

cellular
increased apoptosis ( J:197818 )
• apoptotic megakaryocytes in pIpC-treated mice

behavior/neurological
lethargy ( J:197818 )
• in pIpC-treated mice

cardiovascular system
internal hemorrhage ( J:197818 )
• in pIpC-treated mice




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory