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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdgfratm12Sor
targeted mutation 12, Philippe Soriano
MGI:3838504
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Pdgfratm12Sor/Pdgfra+ 		involves: 129 * C57BL/6 MGI:3838615
cn2
 		Cdkn2atm1Rdp/Cdkn2atm1Rdp
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Pdgfratm12Sor/Pdgfra+ 		involves: 129 * C57BL/6J * SJL MGI:3838621


Genotype
MGI:3838615
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Pdgfratm12Sor/Pdgfra+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (3 available); any Gt(ROSA)26Sor mutation (942 available)
Pdgfratm12Sor mutation (1 available); any Pdgfra mutation (85 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:146617 )
• 6 months after tamoxifen treatment, mice develop intestinal disease and eventually die or are sacrificed

digestive/alimentary system
abnormal cecum morphology ( J:146617 )
• tamoxifen-treated mice exhibit partial or complete fibrosis of the small intestine and cecum unlike in wild-type mice with increased submucosal connective tissue and proportional increase in fibroblast-like cells and collagenous matrix
abnormal small intestine morphology ( J:146617 )
• tamoxifen-treated mice exhibit partial or complete fibrosis of the small intestine and cecum unlike in wild-type mice with increased submucosal connective tissue and proportional increase in fibroblast-like cells and collagenous matrix
intestinal fibrosis ( J:146617 )
• tamoxifen-treated mice exhibit partial or complete fibrosis of the small intestine and cecum unlike in wild-type mice with increased submucosal connective tissue and proportional increase in fibroblast-like cells and collagenous matrix
intestine polyps ( J:146617 )
• in tamoxifen-treated mice

cardiovascular system
cardiac fibrosis ( J:146617 )
• in tamoxifen-treated mice

renal/urinary system
glomerulosclerosis ( J:146617 )
• sclerotic glomeruli in tamoxifen-treated mice
renal glomerulus fibrosis ( J:146617 )
• in tamoxifen-treated mice
renal glomerulus hypertrophy ( J:146617 )
• enlarged glomeruli in tamoxifen-treated mice
renal interstitial fibrosis ( J:146617 )
• in tamoxifen-treated mice

neoplasm
increased sarcoma incidence ( J:146617 )
• at between 44 and 76 weeks of age, 5 of 29 tamoxifen-treated mice develop sarcomas arising from dermis or muscle connective tissue

muscle
skeletal muscle interstitial fibrosis ( J:146617 )
• in tamoxifen-treated mice

respiratory system
pulmonary fibrosis ( J:146617 )
• around the bronchioles in tamoxifen-treated mice

integument
tight skin ( J:146617 )
• in tamoxifen-treated mice




Genotype
MGI:3838621
cn2
Allelic
Composition		 Cdkn2atm1Rdp/Cdkn2atm1Rdp
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Pdgfratm12Sor/Pdgfra+
Genetic
Background		 involves: 129 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (62 available)
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (3 available); any Gt(ROSA)26Sor mutation (942 available)
Pdgfratm12Sor mutation (1 available); any Pdgfra mutation (85 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased sarcoma incidence ( J:146617 )
• all tamoxifen-treated mice develop sarcomas of the skin or muscle connective tissue after 10 to 19 weeks
increased fibrosarcoma incidence ( J:146617 )
• 2 tamoxifen-treated mice develop large intestinal tumors resembling undifferentiated fibrosarcomas

muscle
skeletal muscle interstitial fibrosis ( J:146617 )
• tamoxifen-treated mice develop muscle fibrosis at 10 to 19 weeks of age

integument
skin fibrosis ( J:146617 )
• tamoxifen-treated mice develop skin fibrosis at 10 to 19 weeks of age

digestive/alimentary system
intestinal fibrosis ( J:146617 )
• after 15 weeks, tamoxifen-treated mice exhibit intestinal fibrosis




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory