Phenotypes associated with this allele
skeleton
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N |
• no alterations in bone density or osteoclast differentiation are observed due to a lack of cre expression in osteoclasts
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc1tm3Glm mutation
(1 available);
any
Nfatc1 mutation
(47 available)
Sh3bp2tm1Bjro mutation
(0 available);
any
Sh3bp2 mutation
(35 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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skeleton
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N |
• induction of cre at 10 days of age prevents the diffuse bone loss and focal cystic changes characteristic of mice homozygote for the Sh3bp2tm1Bjro allele
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• bone marrow cells fail to differentiate into osteoclasts in vitro
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• a dramatic reduction in the number of TRAP+ cells is found iin the proximal humerus and distal femur
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immune system
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• bone marrow cells fail to differentiate into osteoclasts in vitro
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• widespread inflammation is observed
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• a dramatic reduction in the number of TRAP+ cells is found iin the proximal humerus and distal femur
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• widespread inflammation is observed
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• widespread inflammation is observed
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• widespread inflammation is observed
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digestive/alimentary system
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• widespread inflammation is observed
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liver/biliary system
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• widespread inflammation is observed
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respiratory system
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• widespread inflammation is observed
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hematopoietic system
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• bone marrow cells fail to differentiate into osteoclasts in vitro
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• a dramatic reduction in the number of TRAP+ cells is found iin the proximal humerus and distal femur
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cellular
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• bone marrow cells fail to differentiate into osteoclasts in vitro
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc1tm3Glm mutation
(1 available);
any
Nfatc1 mutation
(47 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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skeleton
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• after cre induction, osteoclasts fail to develop from bone marrow cells in response to culturing with either osteoblasts, RANKL or M-CSF
• normal numbers of osteoclast progenitors are present in the bone marrow suggesting a defect in differentiation
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• some mice have overgrowth of the upper incisors with short or absent lower incisors
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• some mice have overgrowth of the upper incisors with short or absent lower incisors
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• some mice have overgrowth of the upper incisors with short or absent lower incisors
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• lower mandible has a marked retention of hypertrophic cartilage when cre is induced at 10 days of age
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• the number of osteoclasts per mm bone surface is severely reduced in mice with cre induction at 10 days of age
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• cre induction at 10 days of age leads to growth plate dysplasia, characterized by an increase in thickness, acellular areas, and the retention of hypertrophic chondrocytes beyond the chondro-osseous junction
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• cre-induction at 10 days of age leads to shortened long bones by 5 months of age
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• cre induction at 10 days of age leads to short, club-shaped femurs, with higher radiodensity at the distal portion
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• cre induction at 10 days of age leads to short, club-shaped tibias, with higher radiodensity at the proximal portion
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• the bone volume to total volume fraction of femurs is twice that of controls when cre is induced at 10 days of age
• cre induction at 10 days of age also leads to other features of severe osteopetrosis, including improperly shaped long bones, and a failure to resorb calcified cartilage resulting in aberrant endochondral growth and ossification
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• cre induction at 10 days of age leads to a massive increase in calcified cartilage adjacent to the growth plates
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craniofacial
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• some mice have overgrowth of the upper incisors with short or absent lower incisors
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• some mice have overgrowth of the upper incisors with short or absent lower incisors
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• some mice have overgrowth of the upper incisors with short or absent lower incisors
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• lower mandible has a marked retention of hypertrophic cartilage when cre is induced at 10 days of age
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limbs/digits/tail
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• cre induction at 10 days of age leads to short, club-shaped femurs, with higher radiodensity at the distal portion
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• cre induction at 10 days of age leads to short, club-shaped tibias, with higher radiodensity at the proximal portion
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hematopoietic system
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• after cre induction, osteoclasts fail to develop from bone marrow cells in response to culturing with either osteoblasts, RANKL or M-CSF
• normal numbers of osteoclast progenitors are present in the bone marrow suggesting a defect in differentiation
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• the number of osteoclasts per mm bone surface is severely reduced in mice with cre induction at 10 days of age
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immune system
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• after cre induction, osteoclasts fail to develop from bone marrow cells in response to culturing with either osteoblasts, RANKL or M-CSF
• normal numbers of osteoclast progenitors are present in the bone marrow suggesting a defect in differentiation
|
|
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• the number of osteoclasts per mm bone surface is severely reduced in mice with cre induction at 10 days of age
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cellular
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• after cre induction, osteoclasts fail to develop from bone marrow cells in response to culturing with either osteoblasts, RANKL or M-CSF
• normal numbers of osteoclast progenitors are present in the bone marrow suggesting a defect in differentiation
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growth/size/body
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• some mice have overgrowth of the upper incisors with short or absent lower incisors
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• some mice have overgrowth of the upper incisors with short or absent lower incisors
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• some mice have overgrowth of the upper incisors with short or absent lower incisors
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3tm1Glm mutation
(0 available);
any
Hivep3 mutation
(103 available)
Nfatc1tm3Glm mutation
(1 available);
any
Nfatc1 mutation
(47 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
|
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc1tm3Glm mutation
(1 available);
any
Nfatc1 mutation
(47 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation
(2 available)
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skeleton
|
N |
• mice do not display an osteopetrotic phenotype
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Analysis Tools
