Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2Mak mutation
(4 available);
any
Pten mutation
(81 available)
Tg(Col2a1-cre)1Xya mutation
(0 available)
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mortality/aging
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• death before 18 months from progressive hind limb paralysis
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growth/size/body
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• bodies longer than controls at birth
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limbs/digits/tail
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• 11-14% longer than controls at 40 days of age
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skeleton
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• width of long bones is noticeably greater
• lengths of tibia and femur are normal at 50 days of age
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• 14 cartilaginous nodules in epiphyseal cavities of femurs from 9 mice
• clusters of nonproliferating chondrocytes appear in the central regions of growth plates at 3 days of age
• accelerated proliferation of flat shaped peripheral chondrocytes
• some smaller lower zone chondrocytes recover proliferative ability
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• most mice develop thoracic kyphosis as they age
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• four cartilaginous nodules in the bone marrow cavity of tibias and femora of four mice
• cartilaginous nodules found in close proximity to the metaphyseal growth plates of knee joints
• non hypertrophic cartilagenous clusters penetrating the bone marrow cavity become hypertrophic
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• cartilaginous nodules limited at the periphery by lamellae of well mineralized trabecular bone
• nodules disappear after fusion of growth plates at 6 months
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• neoplastic cores are hypocellular with enlarged balloon-like chondrocytes
• chondrocytes within neoplastic cores are surrounded by fewer collagen fibers
• have a distended and fragmented endoplastic reticulum
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• cartilaginous nodules in bone marrow cavity
• cartilaginous nodules in epiphyseal cavities
• non hypertrophic cartilagenous clusters penetrating the bone marrow cavity become hypertrophic and gradually form pseudogrowth plates
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• growth plates are essentially normal embryonically
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• neoplastic clusters penetrate through the hypertrophic zone into the bone marrow cavity
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neoplasm
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• clusters of "resting" chondrocytes develop into neoplastic cores by day 5
• clusters become more distinct by day 7 and migrate toward epiphyses
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behavior/neurological
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• progressive hind limb paralysis results in death by 18 months
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm3Cxd mutation
(0 available);
any
Fgfr2 mutation
(87 available)
Tg(Col2a1-cre)1Xya mutation
(0 available)
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craniofacial
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• 8-week old skulls show less malformation than 4-week old skulls
• the distance of the paired anterior zygoma is increased by 11.2% and 5.4% in 4- and 8-week old mice, respectively
• the distance between two lacrimal bones is increased by 9.4% in 4-week old mice and shows no changes in 8-week old mice
• the linear distances between the intersection of interparietal and occipital bones at the midline and the posterior palate are decreased 6.4% and 6.6% in 4- and 8-week old mice, respectively
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• mice show growth disturbance in the cranial base by P14
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• P3 mice show shortened sphenooccipital synchondroses
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• 4-week old mice show rostrocaudally shortened, but dorsoventrally increased cranial cavity, indicating a dorsoventrally increased and rostrocaudally shortened brain
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• shortened skull length at 4 weeks of age
• approximately 58% linear distances in the cranium are shortened by over 5%, 33% distances exhibit less than 5% shortening, and 9% distances show over 5% increases in 4-week old mice
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• the length of the lateral neurocranium is decreased 10.2% and the width of the caudal neurocranium is increased by 5.5% in 4-week old mice
• the neurocranium is not reduced along the rostro-caudal axis and has no change along the medial-lateral axis in 8-week old mice
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• shortened basioccipital bone
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• shortened basisphenoid bone
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• the breadth of the frontal bone is mildly increased by 5.4% in 4-week old mice
• the breadth of frontal bone shows no changes in 8-week old mice
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• the length of the frontal bone is mildly decreased by 5.9% in 4-week old mice
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• frontal processes of the maxilla are shortened by 13.9% in 4-week old mice
• frontal processes of the maxilla are shortened by 9.2% in 8-week old mice
• the parietal frontal process of the maxilla is decreased by 7.2% in 8-week old mice
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• the premaxilla length is decreased by 9.3% in 4-week old mice
• the premaxilla length is reduced 11.2% in 8-week old mice
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• maxilla length is decreased by 7.5% in 4-week old mice
• maxilla length is decreased by 8.7% in 8-week old mice
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• abnormal nasal bone at 8 weeks of age
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• the length of the nasal bone is decreased 13.6% in 4-week old mice
• the length of the nasal bone is decreased 12.5% in 8-week old mice
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• the zygomatic bone is shortened by 21.2% in 4-week old mice
• zygomatic bone is shortened by 9.3% in 8-week old mice
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• 8-week old mice show a less severe midfacial shape than 4-week old mice
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growth/size/body
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• abnormal nasal bone at 8 weeks of age
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• the length of the nasal bone is decreased 13.6% in 4-week old mice
• the length of the nasal bone is decreased 12.5% in 8-week old mice
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• 8-week old mice show a less severe midfacial shape than 4-week old mice
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skeleton
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• 8-week old skulls show less malformation than 4-week old skulls
• the distance of the paired anterior zygoma is increased by 11.2% and 5.4% in 4- and 8-week old mice, respectively
• the distance between two lacrimal bones is increased by 9.4% in 4-week old mice and shows no changes in 8-week old mice
• the linear distances between the intersection of interparietal and occipital bones at the midline and the posterior palate are decreased 6.4% and 6.6% in 4- and 8-week old mice, respectively
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• mice show growth disturbance in the cranial base by P14
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• P3 mice show shortened sphenooccipital synchondroses
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• 4-week old mice show rostrocaudally shortened, but dorsoventrally increased cranial cavity, indicating a dorsoventrally increased and rostrocaudally shortened brain
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• shortened skull length at 4 weeks of age
• approximately 58% linear distances in the cranium are shortened by over 5%, 33% distances exhibit less than 5% shortening, and 9% distances show over 5% increases in 4-week old mice
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• the length of the lateral neurocranium is decreased 10.2% and the width of the caudal neurocranium is increased by 5.5% in 4-week old mice
• the neurocranium is not reduced along the rostro-caudal axis and has no change along the medial-lateral axis in 8-week old mice
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• shortened basioccipital bone
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• shortened basisphenoid bone
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• the breadth of the frontal bone is mildly increased by 5.4% in 4-week old mice
• the breadth of frontal bone shows no changes in 8-week old mice
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• the length of the frontal bone is mildly decreased by 5.9% in 4-week old mice
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• frontal processes of the maxilla are shortened by 13.9% in 4-week old mice
• frontal processes of the maxilla are shortened by 9.2% in 8-week old mice
• the parietal frontal process of the maxilla is decreased by 7.2% in 8-week old mice
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• the premaxilla length is decreased by 9.3% in 4-week old mice
• the premaxilla length is reduced 11.2% in 8-week old mice
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• maxilla length is decreased by 7.5% in 4-week old mice
• maxilla length is decreased by 8.7% in 8-week old mice
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• abnormal nasal bone at 8 weeks of age
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• the length of the nasal bone is decreased 13.6% in 4-week old mice
• the length of the nasal bone is decreased 12.5% in 8-week old mice
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• the zygomatic bone is shortened by 21.2% in 4-week old mice
• zygomatic bone is shortened by 9.3% in 8-week old mice
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• bone volume is decreased in calvarial bone due to the rostrocaudally shortened skull, but not change in bone volume ratio is seen
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• premature closure of coronal sutures in P3 mice
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vision/eye
respiratory system
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• abnormal nasal bone at 8 weeks of age
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• the length of the nasal bone is decreased 13.6% in 4-week old mice
• the length of the nasal bone is decreased 12.5% in 8-week old mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl3tm1a(EUCOMM)Hmgu mutation
(0 available);
any
Myl3 mutation
(20 available)
Tg(Col2a1-cre)1Xya mutation
(0 available)
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immune system
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• 6-month-old mice exhibit cartilage destruction which becomes severe at 18 months of age indicating spontaneous age-related osteoarthritis
• cartilage destruction is accompanied by aggravated synovial inflammation but comparable osteophyte maturity as in controls
• expression of senescence, DNA damage, and catabolic markers are decreased in cartilage of aged mice
• however, mice exhibit normal skeletal development, with normal organization of growth plates and normal body weight
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skeleton
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• 6-month-old mice exhibit cartilage destruction which becomes severe at 18 months of age indicating spontaneous age-related osteoarthritis
• cartilage destruction is accompanied by aggravated synovial inflammation but comparable osteophyte maturity as in controls
• expression of senescence, DNA damage, and catabolic markers are decreased in cartilage of aged mice
• however, mice exhibit normal skeletal development, with normal organization of growth plates and normal body weight
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• marker analysis indicates enhanced cellular senescence of chondrocytes
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