All Phenotypes Adar<tm1.1Phs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adar^tm1.1Phs
targeted mutation 1.1, Peter H Seeburg
MGI:3828307

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Adar^em1Stsn/Adar^tm1.1Phs Meox2^tm1(cre)Sor/Meox2⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	MGI:7281842
cn2	Adar^em1Stsn/Adar^tm1.1Phs Ifih1^tm1.1Cln/Ifih1^tm1.1Cln Meox2^tm1(cre)Sor/Meox2⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	MGI:7281845
cn3	Adar^tm1.1Phs/Adar^tm2Phs Tg(Tal1-cre/ERT)42-056Jrg/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3843982
cn4	Adar^tm1.1Phs/Adar^tm2Phs Tg(Mx1-cre)1Cgn/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3828311

Allelic Composition	Adar^em1Stsn/Adar^tm1.1Phs Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adar^em1Stsn mutation (0 available); any Adar mutation (71 available)
Adar^tm1.1Phs mutation (2 available); any Adar mutation (71 available)
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:308678 )

• at weaning

mortality/aging

lethality, complete penetrance ( J:308678 )

• no survival beyond ~84 days

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Aicardi-Goutieres syndrome		DOID:0050629	OMIM:225750 OMIM:610181 OMIM:610329 OMIM:610333 OMIM:612952 OMIM:615010 OMIM:615846 OMIM:PS225750	J:308678

Allelic Composition	Adar^em1Stsn/Adar^tm1.1Phs Ifih1^tm1.1Cln/Ifih1^tm1.1Cln Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adar^em1Stsn mutation (0 available); any Adar mutation (71 available)
Adar^tm1.1Phs mutation (2 available); any Adar mutation (71 available)
Ifih1^tm1.1Cln mutation (2 available); any Ifih1 mutation (43 available)
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:308678 )

N	• normal weight, weight gain and growth

mortality/aging

mortality/aging ( J:308678 )

N	• normal survival

Allelic Composition	Adar^tm1.1Phs/Adar^tm2Phs Tg(Tal1-cre/ERT)42-056Jrg/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adar^tm1.1Phs mutation (2 available); any Adar mutation (71 available)
Adar^tm2Phs mutation (0 available); any Adar mutation (71 available)
Tg(Tal1-cre/ERT)42-056Jrg mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased bone marrow cell number ( J:142338 )

• bone marrow cellularity is reduced in mice after cre induction

abnormal hematopoietic stem cell morphology ( J:142338 )

• the frequency of Lin^- c-Kit⁺Sca-1^- hematopoietic stem cells (HSC) in the bone marrow after cre induction is much lower than controls

• the frequency of Lin^- c-Kit⁺Sca-1⁺ HSC in the bone marrow after cre induction is much higher than controls

• 68% of actively cycling HSCs are apoptotic after cre induction versus 3-13% in control mice

• the bone marrow has many fewer Lin^- c-Kit⁺Sca-1⁺CD34^lo HSC cells

Allelic Composition	Adar^tm1.1Phs/Adar^tm2Phs Tg(Mx1-cre)1Cgn/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:142338 )

• mice die shortly after birth, even in the absence of cre induction by poly(I:C) administration

hematopoietic system

abnormal definitive hematopoiesis ( J:142338 )

• E14.5 fetal liver cells transplanted into wild-type hosts engraft normally but fail to replenish blood leukocytes after cre induction

• two weeks after cre induction, the contribution of the mutant cells to blood leukocytes is diminished by a fourth

• the contribution of these fetal liver cells to peripheral blood cells including myeloid, B-lymphoid and T-lymphoid lineages is negligible after 23 weeks of cre induction

• very few donor derived hematopoetic stem cells are found in the bone marrow after 23 weeks of cre induction

liver/biliary system

liver hypoplasia ( J:142338 )

• E14.5 embryos have slightly lower total liver cellularity even in the absence of cre induction by poly(I:C) administration

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