Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1.1Mis mutation
(0 available);
any
Bmp2 mutation
(26 available)
Bmp2tm1Brd mutation
(0 available);
any
Bmp2 mutation
(26 available)
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mortality/aging
N |
• the expected proportion of trans-heterozygous pups are detected, unlike for mice trans-heterozygous for Bmp2tm1Brd and Bmp2tm1Mis
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1.1Mis mutation
(0 available);
any
Bmp2 mutation
(26 available)
Bmp2tm1Brd mutation
(0 available);
any
Bmp2 mutation
(26 available)
Foxg1tm1(cre)Skm mutation
(2 available);
any
Foxg1 mutation
(28 available)
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hearing/vestibular/ear
N |
• no obvious abnormalities in cochlea morphology is observed
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1.1Mis mutation
(0 available);
any
Bmp2 mutation
(26 available)
Bmp2tm1Brd mutation
(0 available);
any
Bmp2 mutation
(26 available)
Gfi1tm1(cre)Gan mutation
(0 available);
any
Gfi1 mutation
(31 available)
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hearing/vestibular/ear
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• a 6.5 dB shift in threshold is detected at 16kHz in 3-6 month-old mice compared to controls; at 9-10 months, hearing thresholds are comparable to controls
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1.1Mis mutation
(0 available);
any
Bmp2 mutation
(26 available)
Bmp2tm1.2Mis mutation
(0 available);
any
Bmp2 mutation
(26 available)
Tg(Col1a1-cre)1Bek mutation
(1 available)
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skeleton
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• at 2 weeks but not 2-4 months
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• enlarged intervertebral space in the vertebrae
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• slight at 2 weeks
• at 4 months
• in the lumbar vertebrae and hip region
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• smaller unfused at 2 weeks
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• thinner bones at 2 weeks, progressive
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• reduced mesenchymal stem cell population and capacity to differentiate to mature osteoblasts
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• decrease in osteoclasts covering bone surface or number of osteoclasts per unit of bone surface at 2 weeks
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• in the tibia, femur and humerus
• however, cortical thickness is normal
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• fewer mature cuboidal polarized osteoblasts from 5 days to 6 months
• decrease in the region of mature osteoblasts covering the bone surface and number of mature osteoblasts per bone surface at 8 weeks
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• increase in rod-like quality of trabeculae
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• reduced bone mineralizing surface and mineral apposition rate in the bone marrow trabeculae and in the periosteum
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• decreased bone formation
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cardiovascular system
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• decreased vascularization in the bone (diaphysis and metaphysis)
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limbs/digits/tail
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• at 2 weeks but not 2-4 months
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cellular
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• reduced mesenchymal stem cell population and capacity to differentiate to mature osteoblasts
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immune system
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• decrease in osteoclasts covering bone surface or number of osteoclasts per unit of bone surface at 2 weeks
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hematopoietic system
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• decrease in osteoclasts covering bone surface or number of osteoclasts per unit of bone surface at 2 weeks
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