Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bmp2tm1Mis
Name:	bone morphogenetic protein 2; targeted mutation 1, Yuji Mishina
MGI ID:	MGI:3822026
Synonyms:	fn
Gene:	Bmp2  Location: Chr2:133394079-133404805 bp, + strand  Genetic Position: Chr2, 65.21 cM
Alliance:	Bmp2tm1Mis page

Germline Transmission:	Earliest citation of germline transmission: J:141834
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 3 and an frt flanked neo cassette, second loxP site, and a human alkaline phosphatase gene were inserted in the 3' UTR of exon 3. Quantitative RT-PCR indicated a decrease in RNA expression in homozygous embryos. (J:141834)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bmp2 Mutation:	26 strains or lines available

Original:	J:141834 Singh AP, et al., Influences of reduced expression of maternal bone morphogenetic protein 2 on mouse embryonic development. Sex Dev. 2008;2(3):134-41
All:	2 reference(s)