Analysis Tools
mortality/aging
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• in crosses of heterozygous mice the proportion of trans-heterozygous pups is underrepresented; no specific time of lethality was provided
• underrepresentation is more severe when the mother is heterozygous for the null allele
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growth/size/body
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• seen in surviving pups at 38 days of age
|
|
• some embryos develop a body wall hernia in the ventral abdominal region
• frequency of hernias is highest when the mother is heterozygous for the null allele
|
nervous system
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• seen in some pups at E9.5
• frequency of closure defects is highly dependent on the genotype of the mother
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exencephaly
(
J:141834
)
|
• develops by midgestation in embryos with cephalic neural tube closure defects
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limbs/digits/tail
kinked tail
(
J:141834
)
reproductive system
 |
• slightly increased compared to females heterozygous for the null allele only
|
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• dramatically reduced litter size compared to wild-type females
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embryo
|
• seen in some pups at E9.5
• frequency of closure defects is highly dependent on the genotype of the mother
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