Bmp2^tm1.2Mis
Targeted Allele Detail

Summary

• Symbol: Bmp2^tm1.2Mis
• Name: bone morphogenetic protein 2; targeted mutation 1.2, Yuji Mishina
• MGI ID: MGI:5572019
• Synonyms: Bmp2 Rec
• Gene: Bmp2 Location: Chr2:133394079-133404805 bp, + strand Genetic Position: Chr2, 65.21 cM
• Alliance: Bmp2^tm1.2Mis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210409
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3 and an frt flanked neomycin resistance cassette, second loxP site, and a human alkaline phosphatase gene were inserted downstream of exon 3. The neo cassette was removed by flp-mediated recombination. Cre-mediated recombination removed exon 3. (J:210409)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmp2 Mutation: 26 strains or lines available

References

• Original: J:210409 Yang W, et al., Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells. J Cell Sci. 2013 Sep 15;126(Pt 18):4085-98
• All: 1 reference(s)