Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bmp2tm1Brd
Name:	bone morphogenetic protein 2; targeted mutation 1, Allan Bradley
MGI ID:	MGI:1857894
Synonyms:	bmp2m1
Gene:	Bmp2  Location: Chr2:133394079-133404805 bp, + strand  Genetic Position: Chr2, 65.21 cM
Alliance:	Bmp2tm1Brd page

Germline Transmission:	Earliest citation of germline transmission: J:36213
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An HPRT mini-gene cassette replaced a 4.0 kb genomic fragment that contains sequences encoding the entire BMP2 mature region and two thirds of the propeptide. (J:36213)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	77 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bmp2 Mutation:	26 strains or lines available

Original:	J:36213 Zhang H, et al., Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development. 1996 Oct;122(10):2977-86
All:	22 reference(s)