Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Brd mutation
(0 available);
any
Bmp2 mutation
(26 available)
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mortality/aging
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• homozygous mutant embryos die between E7-E10.5
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embryo
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• at E9.5, 9 of 9 homozygotes fail to complete axial turning
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• at E9.5, homozygotes are smaller than wild-type embryos
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• at E9.5, homozygotes display an open neural tube with blood cells in the headfold (probably secondary consequences of heart defect)
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• at E8.5 and E9.5, ~70% of homozygotes retain an open proamniotic canal, leading to chorion malformation
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• at E8.5 and E9.5, ~70% of homozygotes retain an open proamniotic canal
• by E10.5, 2 of 2 homozygotes exhibit an open proamniotic canal
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• at E8.5 and E9.5, all homozygotes display delayed allantois development
• in some cases, the mutant allantois fails to reach the ectoplacental cone
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cardiovascular system
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• at E8.5 and E9.5, 2 of 12 homozygotes display no signs of heart development, despite an apparently normal amnion/chorion formation
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• at E8.5, homozygotes display delayed cardiac development relative to wild-type embryos
• at E9.5, homozygotes still exhibit a single heart tube whereas wild-type embryos show a more differentiated heart consisting of a well-formed AV canal
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• at E8.5 and E9.5, >75% of homozygotes exhibit a disorganized heart that is abnormally positioned in the exocoelomic cavity insted of the putative amniotic cavity
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nervous system
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• at E9.5, homozygotes display an open neural tube with blood cells in the headfold (probably secondary consequences of heart defect)
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growth/size/body
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• at E9.5, homozygotes are smaller than wild-type embryos
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Brd mutation
(0 available);
any
Bmp2 mutation
(26 available)
Bmp2tm1Mis mutation
(1 available);
any
Bmp2 mutation
(26 available)
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mortality/aging
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• in crosses of heterozygous mice the proportion of trans-heterozygous pups is underrepresented; no specific time of lethality was provided
• underrepresentation is more severe when the mother is heterozygous for the null allele
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growth/size/body
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• seen in surviving pups at 38 days of age
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• some embryos develop a body wall hernia in the ventral abdominal region
• frequency of hernias is highest when the mother is heterozygous for the null allele
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nervous system
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• seen in some pups at E9.5
• frequency of closure defects is highly dependent on the genotype of the mother
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• develops by midgestation in embryos with cephalic neural tube closure defects
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limbs/digits/tail
reproductive system
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• slightly increased compared to females heterozygous for the null allele only
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• dramatically reduced litter size compared to wild-type females
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embryo
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• seen in some pups at E9.5
• frequency of closure defects is highly dependent on the genotype of the mother
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1.1Mis mutation
(0 available);
any
Bmp2 mutation
(26 available)
Bmp2tm1Brd mutation
(0 available);
any
Bmp2 mutation
(26 available)
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mortality/aging
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N |
• the expected proportion of trans-heterozygous pups are detected, unlike for mice trans-heterozygous for Bmp2tm1Brd and Bmp2tm1Mis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1.1Mis mutation
(0 available);
any
Bmp2 mutation
(26 available)
Bmp2tm1Brd mutation
(0 available);
any
Bmp2 mutation
(26 available)
Gfi1tm1(cre)Gan mutation
(0 available);
any
Gfi1 mutation
(31 available)
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hearing/vestibular/ear
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• a 6.5 dB shift in threshold is detected at 16kHz in 3-6 month-old mice compared to controls; at 9-10 months, hearing thresholds are comparable to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1.1Mis mutation
(0 available);
any
Bmp2 mutation
(26 available)
Bmp2tm1Brd mutation
(0 available);
any
Bmp2 mutation
(26 available)
Foxg1tm1(cre)Skm mutation
(2 available);
any
Foxg1 mutation
(28 available)
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hearing/vestibular/ear
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N |
• no obvious abnormalities in cochlea morphology is observed
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Allelic
Composition |
Bmp2tm1Brd/Bmp2+
Tbx1tm1Pa/Tbx1+
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Genetic
Background |
involves: 129/Sv * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Brd mutation
(0 available);
any
Bmp2 mutation
(26 available)
Tbx1tm1Pa mutation
(2 available);
any
Tbx1 mutation
(34 available)
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cardiovascular system
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• double heterozygous newborns show malformations in the aortic arch-derived arterial tree at a frequency similar to that observed in mice heterozygous for Tbx1tm1Pa (27% vs 25%, respectively)
• notably, pharyngeal glands appear unaffected in both groups of mice
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craniofacial
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• double heterozygous newborns show malformations in the aortic arch-derived arterial tree at a frequency similar to that observed in mice heterozygous for Tbx1tm1Pa (27% vs 25%, respectively)
• notably, pharyngeal glands appear unaffected in both groups of mice
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embryo
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• double heterozygous newborns show malformations in the aortic arch-derived arterial tree at a frequency similar to that observed in mice heterozygous for Tbx1tm1Pa (27% vs 25%, respectively)
• notably, pharyngeal glands appear unaffected in both groups of mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2tm1Brd mutation
(0 available);
any
Bmp2 mutation
(26 available)
Bmp7tm1Kry mutation
(1 available);
any
Bmp7 mutation
(37 available)
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skeleton
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N |
• doubly heterozygous pups have a normal skeleton and display no rib cage abnormalities or limb defects
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Analysis Tools