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Tbx1tm1Pa
Targeted Allele Detail
Summary
Symbol: Tbx1tm1Pa
Name: T-box 1; targeted mutation 1, Virginia Papaioannou
MGI ID: MGI:2179190
Gene: Tbx1  Location: Chr16:18399729-18409412 bp, - strand  Genetic Position: Chr16, Syntenic
Alliance: Tbx1tm1Pa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70730
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A loxP-flanked neomycin selection cassette replaced most of the coding region of the gene. (J:70730)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 224 assay results
In Structures Affected by this Mutation: 46 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tbx1 Mutation:  34 strains or lines available
References
Original:  J:70730 Jerome LA, et al., DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nat Genet. 2001 Mar;27(3):286-91
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory