Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Telo2tm1.1Tdl mutation
(0 available);
any
Telo2 mutation
(33 available)
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mortality/aging
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• no mice are present at E13.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation
(3 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Telo2tm1.1Tdl mutation
(0 available);
any
Telo2 mutation
(33 available)
Telo2tm1Tdl mutation
(0 available);
any
Telo2 mutation
(33 available)
Trp53tm1Tyj mutation
(12 available);
any
Trp53 mutation
(232 available)
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cellular
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• tamoxifen-treated mouse embryonic fibroblasts exhibit cell cycle arrest after 6 days in culture unlike wild-type cells
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation
(3 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Telo2tm1.1Tdl mutation
(0 available);
any
Telo2 mutation
(33 available)
Telo2tm1Tdl mutation
(0 available);
any
Telo2 mutation
(33 available)
|
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cellular
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• after 3 to 4 days in culture tamoxifen-treated mouse embryonic fibroblasts (MEFs) arrest with 2N or 4N DNA content and exhibit reduced S and M phase unlike wild-type MEFs
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• after 3 to 4 days in culture tamoxifen-treated mouse embryonic fibroblasts (MEFs) exhibit a flattened senescence-like morphology unlike wild-type MEFs
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• tamoxifen-treated mouse embryonic fibroblasts exhibit decreased DNA-damage signaling via Trp53, Cdkn1a and Chek1 compared to wild-type cells
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homeostasis/metabolism