Telo2^tm1.1Tdl
Targeted Allele Detail

Summary

• Symbol: Telo2^tm1.1Tdl
• Name: telomere maintenance 2; targeted mutation 1.1, Titia de Lange
• MGI ID: MGI:3819391
• Synonyms: Tel2^DEL
• Gene: Telo2 Location: Chr17:25318544-25334941 bp, - strand Genetic Position: Chr17, 12.53 cM, cytoband A3.3
• Alliance: Telo2^tm1.1Tdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141633
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Transient cre expression in ES cells was used to remove the floxed exon 3 and the neo cassette. This deletion results in a frame shift and premature termination of translation at amino acid 168 of 840. A two-fold reduction in protein expression levels was confirmed by western blot analysis on embryonic fibroblasts heterozygous for the allele. (J:141633)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Telo2 Mutation: 30 strains or lines available

References

• Original: J:141633 Takai H, et al., Tel2 regulates the stability of PI3K-related protein kinases. Cell. 2007 Dec 28;131(7):1248-59
• All: 1 reference(s)